LIFE - Leipzig Research Center for Civilization Diseases

Resutls of different OMICS-level using LIFE Adult and LIFE Heart data are presented (Publications, Supplemental Data, & Summary Statistics).

Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status

A meta-analysis of genome-wide associations for serum vaspin from six independent cohorts (N = 7446) was conducted. The data show that serum vaspin is strongly determined by genetic variants within vaspin.

This study belongs to the publication: https://doi.org/10.1002/oby.23882

Summary statistics of Meta-GWAS results will be made available upon acceptance of our manuscript.

In our manuscript, we describe current procedures, tools, and results to create, compare and qualitatively assess the single-cell transcriptomes of the lung in three different species; human (Homo sapiens), hamster (Mesocricetus auratus), and mice (Mus musculus). We make the analysis reproducible by publishing the R-based workflow on GitHub pulmonologists_interspecies_scRNA. Here in the LHA, we provide the required scRNA-Seq ...

Genome-wide Association Meta-Analyses of four steroid hormones (progesterone, 17-OH-progesterone, androstenedione, and aldosterone) and the ratio of testosterone to estradiol. Summary statistics of GWAMA results will be made available upon acceptance of our manuscript.

Genome-wide Association Meta-Analyses of 32 phytosterol traits reflecting resorption, cholesterol synthesis and esterification in six studies with up to 9,758 subjects Summary statistics of GWAMA results will be made available upon acceptance of our manuscript.

We analysed if measuring PWV in different segments of the body leads to association with different genetic variants, as well as different heritability and different genetic correlation with other biological traits. Furthermore we searched for shared genetic architecture concerning PWV, blood pressure (BP) and coronary artery disease (CAD) and examined the causal relationship between PWV and BP.

We defined six operationalizations of CPB considering plaques in common carotid arteries, carotid bulb, and internal carotid arteries (maximal plaque area, mean plaque area, sum of plaque areas at all six regions, maximal degree of stenosis, mean degree of stenosis, and sum of stenosis at all six regions). Link to publication (PMID, DOI), Supplemental Figures and Tables, and Summary Statistics of GWAS will be made available upon acceptance of our manuscript.

Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)

Summary Statistics used in publication

To provide data input and result from a scRNA-Seq integration workflow

We are releasing the summary data from our GWAMA of PCSK9 levels, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.

Citation: tba

When using this data acknowledge the source as follows: 'Data on PCSK9 has been downloaded from https://www.health-atlas.de/data_files/551.'

For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) ...

We are releasing the summary data from our GWAMA of phytosterol traits, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.

Citation: tba

When using this data acknowledge the source as follows: 'Data on phytosterol X has been contributed by LIFE investigators and has been downloaded from https://www.health-atlas.de/assays/53.'

For any enquiries about ...

Summary statistics from GWAS of baPWV, bfPWV, cfPWV All samples (adjusted for age, sex and log_sys)

These data is intended for research purposes only.

Citation: tbc

When using this data acknowledge the source as follows: 'Data on PWV has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/34'

For any enquiries about the datasets, please contact Michael Rode (michael.rode@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de) ...

We are releasing the summary data from our GWAS of carotid plaque burden traits, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.

Citation:

When using this data acknowledge the source as follows: 'Data on carotid plaque burden has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/31 '

For any ...

Data used in following publication: https://doi.org/10.1002/oby.23882

BACKGROUND: The Generalized Anxiety Disorder Scales GAD-7 and GAD-2 are instruments for the assessment of anxiety. The aims of this study are to test psychometric properties of these questionnaires, to provide normative values, and to investigate associations with sociodemographic factors, quality of life, psychological variables, and behavioral factors. METHODS: A German community sample (n=9721) with an age range of 18-80 years was surveyed using the GAD-7 and several other questionnaires. ...

BACKGROUND: The Pittsburgh Sleep Quality Index (PSQI) is frequently used to assess sleep problems in patients. The aim of this study was to provide reference values for this questionnaire, to test psychometric properties, and to analyze associations with psychological, sociodemographic, and behavioral factors. METHODS: A German community sample comprising 9284 adult residents (aged 18-80 years) was surveyed using the PSQI and several other questionnaires. RESULTS: According to the generally ...

Background/Objective: The Life Orientation Test-Revised (LOT-R) is often used to assess dispositional optimism. The aims of this study were to test psychometric properties of the LOT-R, to provide normative scores, and to test the association between optimism and several psychological, sociodemographic, and behavioral factors. Method: A randomly selected German general population community sample with an age range of 18-80 years (N = 9,711) was surveyed. Results: The Confirmatory Factor Analysis ...

The goal of this study was to investigate to what extent body mass index (BMI), body height, body weight, breast-to-abdomen-ratio, testosterone, estradiol, dehydroepiandrosterone-sulfate (DHEA-S), folliclestimulating hormone, and luteinizing hormone are associated with the sound pressure level and the fundamental frequency of the speaking voice in a cross-sectional approach among adults in the general population.

Data for Publication: Jost L, et al; J Voice. 2017 Jul 21. pii: S0892-1997(17)30216-3. ...

PURPOSE: The Sniffin' Sticks Screening 12 test is a test of olfactory performance based on pen-like odor dispensing devices. The aims of this study were to analyze the performance of this test in a general population sample and to explore associations between olfactory dysfunction and quality of life. METHODS: A large community sample (n = 7267) completed the Sniffin' Sticks Screening 12 test and several questionnaires measuring quality of life, anxiety, dispositional optimism, social support, ...

Large scale epidemiological studies, such as LIFE-ADULT, including thousands of participants with a multitude of novel QT assessments allow to define reference values. Reference values are typically used in quality control to find outliers in a specified data volume or to evaluate a given measurement value regarding its pathologic value. Measuring the hand grip strength is a standard assessment in LIFE, for which is no or little prior knowledge regarding reference values available.

Based on the ...

This package should simplify the translation of the classifications reported in Wichmann et al. 2015 to other data sets of head and neck cancers.

Classification of head and neck tumor samples into HPV-positive and negative samples based on their gene expression. Classification of the samples into molecular subgroups reported in Wichmann et al. 2015

Emerging health geography research analyzes and visualizes health behaviors and outcomes in relation to urban environmental data and related official statistics to produce “health reports” for specific areas. This can be extended to developments in urban planning, e.g., to identify districts or neighborhoods for social investments or restrictions.

We mapped anthropometric data the large LIFE Adult population (10,000 participants) onto the Leipzig map. In particular, we derived the body mass index ...

All studies and research projects those data are hosted by the Leipzig Health Atlas should follow the FAIR standard. Thus, data are findable, accessible, interoperable, and reusable. To follow the FAIR standard, all data need to be described by rich metadata, on the technical and semantical level. These metadata can then be used to query and search for data elements in a single study or over all studies.

We provide the LHA data portal allowing to searching and accessing data elements in single ...

Emerging health geography research analyzes and visualizes health behaviors and outcomes in relation to urban environmental data and related official statistics to produce “health reports” for specific areas.

We mapped measured hand grip data of the large LIFE Adult population (10,000 participants) onto the Leipzig map. In particular, we locate each participant at the time of participation in Leipzig and, thus, can derive hand grip strength averages (incl. mean, median) per specific city districts. ...

The LHA Body typer is an interactive app that enables interested users to determine their body type by manual measuring of few body lengths and girths. Additionally, data derived from body scanner devices can be uploaded for automatic body type annotation with regard to the body shapes identified in the Leipzig population.