head and neck cancer
Details about this human disease
Synonyms (4)head and neck tumours, head and neck neoplasm, tumor of head and neck (disorder), head/neck neoplasm
Definitions (1)
An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx.
Related items
The aim of the Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) is to facilitate improvements in the treatment and care of head and neck cancer patients through insights from molecular studies.
The Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) investigates the molecular mechanisms and the diagnostic and prognostic factors of head and neck cancer. For this purpose, we collected phenotypic information from about 300 ...
Programme: LIFE Management Cluster
Public web page: http://life.uni-leipzig.de/
Start date: 1st Jan 2012
End date: 31st Dec 2012
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: head and neck squamous cell carcinomas
Study: HNSCC
Submitter: René Hänsel
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: head and neck squamous cell carcinomas
Study: HNSCC
Abstract (Expand)
Authors: G. Wichmann, M. Rosolowski, K. Krohn, M. Kreuz, A. Boehm, A. Reiche, U. Scharrer, D. Halama, J. Bertolini, U. Bauer, D. Holzinger, M. Pawlita, J. Hess, C. Engel, D. Hasenclever, M. Scholz, P. Ahnert, H. Kirsten, A. Hemprich, C. Wittekind, O. Herbarth, F. Horn, A. Dietz, M. Loeffler
Our first objective was to compare the molecular features of subgroups of HNSCC defined by their HPV16 DNA and RNA status. The second objective was to identify gene expression subtypes in HNSCC and to correlate them with other characteristics of the patients.
HPV DNA and RNA status, mutations of 50 genes, survival and other clinical characteristics of 270 patients with head and neck cancer.
Creator: Maciej Rosolowski
Submitter: Christoph Beger
Data file type: Clinical Data
Human Diseases: head and neck squamous cell carcinoma
Download
Creator: Maciej Rosolowski
Submitter: Maciej Rosolowski
Data file type: SOM Data
Human Diseases: head and neck squamous cell carcinoma
External Link
This package should simplify the translation of the classifications reported in Wichmann et al. 2015 to other data sets of head and neck cancers.
Classification of head and neck tumor samples into HPV-positive and negative samples based on their gene expression. Classification of the samples into molecular subgroups reported in Wichmann et al. 2015
Creator: Maciej Rosolowski
Submitter: René Hänsel
Model type: Not specified
Model format: R package
Environment: Not specified
