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**Created**: 18th Sep 2020 at 13:06

**Last updated**: 18th Sep 2020 at 13:06

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#### Version 1 Created 18th Sep 2020 at 13:06 by Andreas Kühnapfel

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Goal of the Leipzig Research Center for Civilization Diseases (LIFE) is the investigation of civilization diseases like depression, diabetes, allergies or cardiovascular diseases. For this purpose we collect as much data as possible regarding health and living conditions of the population in Leipzig and provide these data for scientists of the University of Leipzig and other research institutions.

This population-based study examined 10,000 participants randomly selected from the Leipzig population (2011 to 2014). A follow-up is to be carried out from 2017 - 2020. The study mainly included people aged between 40 and 79. All participants underwent a 6-hour study program and people over 60 years of age were invited two more times to in-depth study of cognition and depression and the brain (MRI, EEG). Extensive measurements of genome, metabolome and transcriptome are available. The LIFE-ADULT ...

**Programme**: Epidemiology

**Public web page**: http://life.uni-leipzig.de/en/adults/life_adult.html

**Start date**: 1st Jan 2009

**Organisms:** Homo sapiens

**Human Diseases:** mood disorder, dementia, coronary artery disease, obesity

The group is interested in omic-level studies including the genome, methylome, transcriptome, and metabolome of the general population as well as of various diseases including cardiovascular diseases, pneumonia, sepsis, obesity, and brain cancers. Additionally, we aim at transfering results of biomathematical model simulations into clinical practice e.g. by haematopoietic growth-factor opimization during cytotoxic chemotherapy and optimization of EPO applications in chronic kidney disease.

The ...

**Programme**: This Project is not associated with a Programme

**Public web page**: http://www.imise.uni-leipzig.de/en/Groups/GenStat/

**Start date**: 1st Jan 2013

**Organisms:** Homo sapiens

Resutls of different OMICS-level using LIFE Adult and LIFE Heart data are presented (Publications, Supplemental Data, & Summary Statistics).

**Submitter**: René Hänsel

**Studies:** DNA methylation patterns reflect individual lifestyle independent from o..., GWAMA PCSK9, GWAMA Phytosterole, GWAMA Steroid hormones, GWAS Body Scanner Measures, GWAS Carotid Plaque Burden, GWAS Pulse Wave Velocity, GWAS Steroid Hormones, scRNA-Seq across species for pulmonologists

**Resources:** Gene Expression data, LIFE-Adult EPIC data, Summary Statistic for PWV GWAS, Summary Statistics, Summary Statistics, Summary Statistics, Summary Statistics, Summary Statistics - Phytosterols, Supplement Data, scRNA-Seq expression data as RDS Seurat file

**Snapshots: **No snapshots

**Submitter**: Janne Pott

**Investigation:** OMICS Investigations

**Resources:** Summary Statistics

**Study type:**
Genetic study

**Snapshots: **No snapshots

**Submitter**: Andreas Kühnapfel

**Biological problem addressed**: Genome Scale

**Investigation:** OMICS Investigations

**Study:** GWAS Body Scanner Measures

**Human Diseases**: No human diseases

**Models:** No Models

**SOPs:** No SOPs

**Data files:** BS Abbreviations, Summary Statistics for BS_3D_WAISTBAND, Summary Statistics for BS_3D_WAISTBAND_AVERAGE_..., Summary Statistics for BS_3D_WAISTBAND_B_HT, Summary Statistics for BS_3D_WAISTBAND_F_HT, Summary Statistics for BS_AC_BACK_WTH, Summary Statistics for BS_AC_BACK_WTH_AL, Summary Statistics for BS_ANKLE_GTH_AVERAGE, Summary Statistics for BS_ANKLE_HT, Summary Statistics for BS_ARM_LTH_AVERAGE, Summary Statistics for BS_ARM_LTH_T_NECK_AVERAGE, Summary Statistics for BS_ARM_LTH_T_NECK_B_AVERAGE, Summary Statistics for BS_BELLY_CIRC, Summary Statistics for BS_BELLY_CIRC_HT, Summary Statistics for BS_BMI, Summary Statistics for BS_BREAST_HT, Summary Statistics for BS_BUST_CHEST_GTH, Summary Statistics for BS_BUST_CHEST_GTH_HZ, Summary Statistics for BS_BUST_PT_AR_NECK, Summary Statistics for BS_BUST_PT_T_NECK_AVERAGE, Summary Statistics for BS_BUST_PT_WTH, Summary Statistics for BS_BUTTOCK_GTH, Summary Statistics for BS_BUTTOCK_HT, Summary Statistics for BS_CALF_GTH_AVERAGE, Summary Statistics for BS_CROTCH_HT, Summary Statistics for BS_CROTCH_LTH, Summary Statistics for BS_CROTCH_LTH_AT_WB, Summary Statistics for BS_CROTCH_LTH_AT_WB_A, Summary Statistics for BS_CROTCH_LTH_F, Summary Statistics for BS_CROTCH_LTH_R, Summary Statistics for BS_CR_SHOULDER, Summary Statistics for BS_CR_SHOULDER_O_NECK, Summary Statistics for BS_DEV_WB_FROM_WAIST_B, Summary Statistics for BS_DEV_WB_FROM_WAIST_F, Summary Statistics for BS_DEV_WB_FROM_WAIST_S, Summary Statistics for BS_DIST_AC_B_WTH_WAIST, Summary Statistics for BS_DIST_CROTCH_WAISTBAN, Summary Statistics for BS_DIST_NECK_KNEE, Summary Statistics for BS_DIST_NECK_T_HIP, Summary Statistics for BS_DIST_WAISTBAND_BUTT, Summary Statistics for BS_DIST_WAISTBAND_KNEE, Summary Statistics for BS_DIST_WAIST_KNEE, Summary Statistics for BS_ELBOW_GTH_AVERAGE, Summary Statistics for BS_FOREARM_GTH_AVERAGE, Summary Statistics for BS_FOREARM_LTH_AVERAGE, Summary Statistics for BS_HEAD_CIRC, Summary Statistics for BS_HEAD_HT, Summary Statistics for BS_HIGH_HIP_GTH, Summary Statistics for BS_HIGH_WAIST_GTH, Summary Statistics for BS_HIGH_WAIST_HT, Summary Statistics for BS_HIP_GTH, Summary Statistics for BS_HIP_HT, Summary Statistics for BS_HIP_THIGH_GTH, Summary Statistics for BS_HT, Summary Statistics for BS_HT_SHOULDER_BLADES, Summary Statistics for BS_INSEAM_AVERAGE, Summary Statistics for BS_IN_LEG_ANKLE_AVERAGE, Summary Statistics for BS_KNEE_GTH_AVERAGE, Summary Statistics for BS_KNEE_HT, Summary Statistics for BS_MAX_BELLY_CIRC, Summary Statistics for BS_MAX_BELLY_CIRC_HT, Summary Statistics for BS_MIDDLE_HIP, Summary Statistics for BS_MID_NECK_GTH, Summary Statistics for BS_MIN_LEG_GTH_AVERAGE, Summary Statistics for BS_NECK_AC_BACK_WTH_AL, Summary Statistics for BS_NECK_AT_BASE_GTH, Summary Statistics for BS_NECK_AVERAGE_T_WAIST_B, Summary Statistics for BS_NECK_DIAM, Summary Statistics for BS_NECK_F_T_WAIST, Summary Statistics for BS_NECK_F_T_WAIST_OV_BL, Summary Statistics for BS_NECK_HT, Summary Statistics for BS_NECK_R_WAIST_OV_BL, Summary Statistics for BS_NECK_WAIST_C_BACK, Summary Statistics for BS_SCAPULA_HT_2, Summary Statistics for BS_SIDESEAM_3D_WD_AVERAGE, Summary Statistics for BS_SIDESEAM_ANKLE_AVERAGE, Summary Statistics for BS_SIDESEAM_AVERAGE, Summary Statistics for BS_SIDESEAM_WAIST_AVERAGE, Summary Statistics for BS_THIGH_GTH_AVERAGE_HZ, Summary Statistics for BS_TORSO_WTH_WAIST, Summary Statistics for BS_TOT_TORSO_GTH, Summary Statistics for BS_UNDERBUST_CIRC_HZ, Summary Statistics for BS_UP_ARM_DIAM_AVERAGE, Summary Statistics for BS_UP_ARM_GTH_AVERAGE, Summary Statistics for BS_UP_ARM_LTH_AVERAGE, Summary Statistics for BS_WAISTBAND, Summary Statistics for BS_WAISTBAND_B_HT, Summary Statistics for BS_WAISTBAND_F_HT, Summary Statistics for BS_WAISTBAND_HT, Summary Statistics for BS_WAIST_BUTTOCK_HT_AVERAGE, Summary Statistics for BS_WAIST_GTH, Summary Statistics for BS_WAIST_HT, Summary Statistics for BS_WAIST_T_BUTTOCK, Summary Statistics for BS_WAIST_T_HIGH_HIP_B, Summary Statistics for BS_WB_BUTTOCK_HT_AVERAGE, Summary Statistics for BS_WRIST_GTH, Summary Statistics for BS_WRIST_GTH_AVERAGE, Summary Statistics for BS_WT, Summary Statistics for BS_WTH, Summary Statistics for BS_WTH_THIGH_AVERAGE

**Snapshots: **No snapshots

**Projects:** LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE Heart, Genetical Statistics and Systems Biology

**Institutions:** Institute for Medical Informatics, Statistics and Epidemiology (IMISE)

**Projects:** LIFE Heart, LIFE - Leipzig Research Center for Civilization Diseases, SepNet - German Competence Network Sepsis, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, LIFE Adult

**Web page**: Not specified