Programme: This Project is not associated with a Programme
LHA ID: 7RU97PWEMJ-6
Funding codes:- German Federal Ministry of Education and Science (BMBF grant 031 6065A)
Public web page: Not specified
Human Diseases: Lynch syndrome, Colorectal cancer
Health Atlas - Local Data Hub/Leipzig PALs: Hans Binder
Project Coordinators: No Project coordinators for this Project
Project created: 26th Apr 2019
Related items
Abstract (Expand)
Authors: L. Nersisyan, L. Hopp, H. Loeffler-Wirth, J. Galle, M. Loeffler, A. Arakelyan, H. Binder
PubMed ID: 31750255
Citation: Front Oncol. 2019 Nov 5;9:1172. doi: 10.3389/fonc.2019.01172. eCollection 2019.
Abstract (Expand)
Authors: H. Loffler-Wirth, M. Kalcher, H. Binder
Date Published: 1st Oct 2015
Publication Type: Not specified
PubMed ID: 26063839
Citation: Bioinformatics. 2015 Oct 1;31(19):3225-7. doi: 10.1093/bioinformatics/btv342. Epub 2015 Jun 10.
Abstract (Expand)
Authors: Lydia Hopp, Henry Löffler-Wirth, M. Fasold, Hans Binder
Date Published: 27th Jan 2014
Publication Type: Not specified
Human Diseases: brain glioma, prostate cancer
DOI: 10.4161/sysb.25897
Citation:
Colorectal cancer (CRC) arising in Lynch syndrome (LS) comprises tumours with constitutional mutations in DNA mismatch repair genes. There is still a lack of whole-genome and transcriptome studies of LS-CRC to address questions about similarities and differences in mutation and gene expression characteristics between LS-CRC and sporadic CRC, about the molecular heterogeneity of LS-CRC, and about specific mechanisms of LS-CRC genesis linked to dysfunctional mismatch repair in LS colonic mucosa and ...
Creator: Hans Binder
Submitter: Henry Löffler-Wirth
Data file type: SOM Data
Human Diseases: Lynch syndrome
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Analysis of large-scale molecular biological data using self-organizing maps
Comprehensive analysis of genome-wide molecular data challenges bioinformatics methodology in terms of intuitive visualization with single-sample resolution, biomarker selection, functional information mining and highly granular stratification of sample classes. oposSOM combines those functionalities making use of a comprehensive analysis and visualization strategy based on self-organizing maps (SOM) machine learning ...
Creator: Henry Löffler-Wirth
Submitter: Henry Löffler-Wirth
Model type: Not specified
Model format: R package
Environment: Shiny
Organism: Not specified
Human Disease: Not specified
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Projects: Leipzig Melanoma Studies, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, CapSys - Systems Medicine of Community Acquired Pneumonia, e:Med, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, oBIG - omics Bioinformatics for Health
Institutions: Interdisciplinary Center for Bioinformatics (IZBI)
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Projects: HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia, e:Med, Fundus photography as tool for analysis of eyes of subjects with diabetes, Clinical Trials Leipzig, NFDI4Health, NFDI4Health - TA3 Services, POLAR - Polypharmacy, Drug Interactions, Risks, STOP-NUC, SCALE-TORT, CapSys - Systems Medicine of Community Acquired Pneumonia, LHA - Leipzig Health Atlas, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, LIFE Child, GLA - German Lymphoma Alliance, MMML-MYC-SYS, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, MMML - Molecular mechanisms in malignant lymphoma, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, NLP4CR - Natural Language Processing for Clinical Research, LIFE Heart, ProstataCA, SepNet - German Competence Network Sepsis, Genetical Statistics and Systems Biology, GGN - German Glioma Network, Task Force COVID-19 Leipzig, SMITH - Smart Medical Information Technology for Healthcare, Management of health information systems, LivSys Transfer - Transfer of the LivSys in vitro system for hepatotoxicity into application, Project Test Demonstrator
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
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Roles: Technician
Expertise: Data Management, Data analysis, Python, Html
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_9256
Definitions: Xref MGI. OMIM mapping confirmed by DO. [SN]., A large intestine cancer that is located_in the colon and/or located_in the rectum.
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_3883
Synonyms: Hereditary Defective Mismatch Repair syndrome, COCA 1, HNPCC - hereditary nonpolyposis colon cancer, hereditary nonpolyposis colorectal neoplasm, hereditary non-polyposis colon cancer type 1, hereditary nonpolyposis colorectal cancer
Definitions: An autosomal dominant disease that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers., OMIM mapping confirmed by DO. [SN].