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head and neck squamous cell carcinomas

Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status

LHA ID: 803RKG0D60-6

Projects: LIFE HNC - Head and Neck Cancer Group

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Creators and Submitter

Creator

Maciej Rosolowski

Submitter

René Hänsel

Activity

Views: 2179

Created: 4th Dec 2019 at 14:04

Last updated: 4th Dec 2019 at 14:42

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Projects (2)
Studies (1)
Resources (2+1)
Publications (1)
Data files (6)
Models (1)
Documents (1)
People (2)
Programmes (1)

LIFE HNC - Head and Neck Cancer Group

The aim of the Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) is to facilitate improvements in the treatment and care of head and neck cancer patients through insights from molecular studies.

The Head and Neck Group within the Leipzig Research Center for Civilization Diseases (LIFE) investigates the molecular mechanisms and the diagnostic and prognostic factors of head and neck cancer. For this purpose, we collected phenotypic information from about 300 ...

Programme: LIFE Management Cluster

Public web page: http://life.uni-leipzig.de/

Start date: 1st Jan 2012

End date: 31st Dec 2012

Organisms: Homo sapiens

Human Diseases: head and neck cancer

LIFE - Leipzig Research Center for Civilization Diseases

Goal of the Leipzig Research Center for Civilization Diseases (LIFE) is the investigation of civilization diseases like depression, diabetes, allergies or cardiovascular diseases. For this purpose we collect as much data as possible regarding health and living conditions of the population in Leipzig and provide these data for scientists of the University of Leipzig and other research institutions.

Programme: LIFE Management Cluster

Public web page: http://life.uni-leipzig.de/

Start date: 1st Jan 2009

Organisms: Homo sapiens

Human Diseases: disease of anatomical entity, disease of cellular proliferation, disease of mental health, disease of metabolism, disease by infectious agent

HNSCC

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status

Submitter: René Hänsel

Investigation: head and neck squamous cell carcinomas

Resources: HNSCC Clinical Dataset, HNSCC OMICS Data

Study type: Clinical study (Phase 1)

Snapshots: No snapshots

Created: 4th Dec 2019 at 14:06, Last updated: 4th Dec 2019 at 14:06

HNSCC Clinical Dataset

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

No description specified

Submitter: René Hänsel

Resource type: Experimental Assay Type

Technology type: Technology Type

Investigation: head and neck squamous cell carcinomas

Study: HNSCC

Human Diseases: head and neck squamous cell carcinoma

Data files: GSE 65858 CSV, GSE 65858 ODM, GSE 65858 XLS, Gene expression patterns and TP53 mutations are...

Snapshots: No snapshots

Created: 4th Dec 2019 at 14:10, Last updated: 15th Apr 2021 at 10:56

HNSCC OMICS Data

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

No description specified

Submitter: René Hänsel

Resource type: Experimental Assay Type

Technology type: Technology Type

Investigation: head and neck squamous cell carcinomas

Study: HNSCC

Human Diseases: head and neck squamous cell carcinoma

Data files: Gene expression patterns and TP53 mutations are..., SOM Analysis Results of Head and Neck Squamous ...

Snapshots: No snapshots

Created: 4th Dec 2019 at 14:19, Last updated: 15th Apr 2021 at 10:50

1 hidden item

The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer.

LIFE HNC - Head and Neck Cancer Group, Genetical Statistics and Systems Biology

(Show All)

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Markus Löffler

Maciej Rosolowski

Markus Scholz

Markus Kreuz

Christoph Engel

Abstract (Expand)

Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status, gene expression patterns, and mutated candidate genes may facilitate patient treatment decision. We … characterize head and neck squamous cell carcinomas (HNSCC) with different HPV16 DNA and RNA (E6*I) status from 290 consecutively recruited patients by gene expression profiling and targeted sequencing of 50 genes. We show that tumors with transcriptionally inactive HPV16 (DNA+ RNA-) are similar to HPV-negative (DNA-) tumors regarding gene expression and frequency of TP53 mutations (47%, 8/17 and 43%, 72/167, respectively). We also find that an immune response-related gene expression cluster is associated with lymph node metastasis, independent of HPV16 status and that disruptive TP53 mutations are associated with lymph node metastasis in HPV16 DNA- tumors. We validate each of these associations in another large data set. Four gene expression clusters which we identify differ moderately but significantly in overall survival. Our findings underscore the importance of measuring the HPV16 RNA (E6*I) and TP53-mutation status for patient stratification and identify associations of an immune response-related gene expression cluster and TP53 mutations with lymph node metastasis in HNSCC.

Authors: G. Wichmann, M. Rosolowski, K. Krohn, M. Kreuz, A. Boehm, A. Reiche, U. Scharrer, D. Halama, J. Bertolini, U. Bauer, D. Holzinger, M. Pawlita, J. Hess, C. Engel, D. Hasenclever, M. Scholz, P. Ahnert, H. Kirsten, A. Hemprich, C. Wittekind, O. Herbarth, F. Horn, A. Dietz, M. Loeffler

Date Published: 15th Dec 2015

Publication Type: Not specified

Human Diseases: head and neck cancer

PubMed ID: 26095926

Citation: Int J Cancer. 2015 Dec 15;137(12):2846-57. doi: 10.1002/ijc.29649. Epub 2015 Jul 6.

Created: 25th Apr 2019 at 12:24, Last updated: 7th Dec 2021 at 17:58

GSE 65858 ODM

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

Our first objective was to compare the molecular features of subgroups of HNSCC defined by their HPV16 DNA and RNA status. The second objective was to identify gene expression subtypes in HNSCC and to correlate them with other characteristics of the patients.

HPV DNA and RNA status, mutations of 50 genes, survival and other clinical characteristics of 270 patients with head and neck cancer.

Creator: Maciej Rosolowski

Submitter: René Hänsel

Data file type: ODM Data

Investigations: head and neck squamous cell carcinomas

Studies: HNSCC

Resources: HNSCC Clinical Dataset

Download

Created: 4th Dec 2019 at 14:37, Last updated: 6th Dec 2019 at 13:16

GSE 65858 CSV

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

HPV DNA and RNA status, mutations of 50 genes, survival and other clinical characteristics of 270 patients with head and neck cancer.

Creator: Maciej Rosolowski

Submitter: René Hänsel

Data file type: Clinical Data

Investigations: head and neck squamous cell carcinomas

Studies: HNSCC

Resources: HNSCC Clinical Dataset

Download

Created: 4th Dec 2019 at 14:34, Last updated: 5th Dec 2019 at 02:48

GSE 65858 XLS

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

HPV DNA and RNA status, mutations of 50 genes, survival and other clinical characteristics of 270 patients with head and neck cancer.

Creator: Maciej Rosolowski

Submitter: René Hänsel

Data file type: Clinical Data

Investigations: head and neck squamous cell carcinomas

Studies: HNSCC

Resources: HNSCC Clinical Dataset

Download

Created: 4th Dec 2019 at 14:29, Last updated: 5th Dec 2019 at 02:47

Gene expression patterns and TP53 mutations are associated with HPV RNA status, lymph node metastasis, and survival in head and neck cancer (clinical Dataset)

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

HPV DNA and RNA status, mutations of 50 genes, survival and other clinical characteristics of 270 patients with head and neck cancer.

Creator: Maciej Rosolowski

Submitter: Christoph Beger

Data file type: Clinical Data

Human Diseases: head and neck squamous cell carcinoma

Investigations: head and neck squamous cell carcinomas

Studies: HNSCC

Resources: HNSCC Clinical Dataset

Download

Created: 13th May 2019 at 14:09, Last updated: 4th Dec 2019 at 11:55

SOM Analysis Results of Head and Neck Squamous Cell Carcinomas

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

No description specified

Creator: Maciej Rosolowski

Submitter: Maciej Rosolowski

Data file type: SOM Data

Human Diseases: head and neck squamous cell carcinoma

Investigations: head and neck squamous cell carcinomas

Studies: HNSCC

Resources: HNSCC OMICS Data

External Link

Created: 20th May 2019 at 13:22, Last updated: 20th May 2019 at 13:22

Gene expression patterns and TP53 mutations are associated with HPV RNA status, lymph node metastasis, and survival in head and neck cancer

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

Gene expression of 270 patients with head and neck cancer Within the Leipzig Head and Neck Group (LHNG) we designed an observational cohort study to include consecutive patients with primary and metachronous secondary HNSCC of oral cavity, larynx, oro-, and hypopharynx. All tumors were pathohistologically classified as head and neck squamous cell carcinoma (ICDO-M-8070/3, 8071/3, 8083/3). Excluded from the study were patients with prior history of cancer other than HNSCC within the last 5 years. ...

Creator: Maciej Rosolowski

Submitter: René Hänsel

Data file type: Other OMICs Data

Investigations: head and neck squamous cell carcinomas

Studies: HNSCC

Resources: HNSCC OMICS Data

Download

Created: 25th Apr 2019 at 12:36, Last updated: 20th May 2019 at 11:46

LHAhpv16classifier - gene expression based predictor of the HPV16 status and of the molecular subgroup (as reported in Wichmann et al. 2015) of head and neck tumor samples

LIFE HNC - Head and Neck Cancer Group

All creators

Maciej Rosolowski

This package should simplify the translation of the classifications reported in Wichmann et al. 2015 to other data sets of head and neck cancers.

Classification of head and neck tumor samples into HPV-positive and negative samples based on their gene expression. Classification of the samples into molecular subgroups reported in Wichmann et al. 2015

Creator: Maciej Rosolowski

Submitter: René Hänsel

Model type: Not specified

Model format: R package

Environment: Not specified

Organism: Not specified

Human Disease: head and neck cancer

Investigations: head and neck squamous cell carcinomas

Studies: HNSCC

Resources: 1 hidden item

Download

Created: 13th May 2019 at 14:57, Last updated: 28th Jan 2022 at 15:21