OMICS Investigations
Genome wide association studies (GWAS) are hypothesis-free methods for identifing associations between genetic regions (loci) and traits (including diseases).
Resutls of different OMICS-level using LIFE Adult and LIFE Heart data are presented (Publications, Supplemental Data, & Summary Statistics).
LHA ID: 7WAD3R7GH9-5
Projects: Genetical Statistics and Systems Biology, LIFE Adult, LIFE Heart
Investigation position:
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Created: 16th May 2019 at 16:39
Last updated: 9th Sep 2020 at 12:15
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The LIFE-Heart study recruited 7,000 patients with suspected coronary heart disease, manifest heart disease or myocardial infarction. All patients received coronary angiography so that the vascular status in the heart is precisely known. In principle, this examination is not feasible in population-related studies. In addition, the patients were thoroughly examined with regard to the general vascular status and the health of the cardiovascular system. Extensive environmental factors were recorded. ...
Programme: LIFE Management Cluster
Public web page: http://life.uni-leipzig.de/
Start date: 1st Jan 2009
Goal of the Leipzig Research Center for Civilization Diseases (LIFE) is the investigation of civilization diseases like depression, diabetes, allergies or cardiovascular diseases. For this purpose we collect as much data as possible regarding health and living conditions of the population in Leipzig and provide these data for scientists of the University of Leipzig and other research institutions.
Programme: LIFE Management Cluster
Public web page: http://life.uni-leipzig.de/
Start date: 1st Jan 2009
This population-based study examined 10,000 participants randomly selected from the Leipzig population (2011 to 2014). A follow-up is to be carried out from 2017 - 2020. The study mainly included people aged between 40 and 79. All participants underwent a 6-hour study program and people over 60 years of age were invited two more times to in-depth study of cognition and depression and the brain (MRI, EEG). Extensive measurements of genome, metabolome and transcriptome are available. The LIFE-ADULT ...
Programme: LIFE Management Cluster
Public web page: http://life.uni-leipzig.de/en/adults/life_adult.html
Start date: 1st Jan 2009
The group is interested in omic-level studies including the genome, methylome, transcriptome, and metabolome of the general population as well as of various diseases including cardiovascular diseases, pneumonia, sepsis, obesity, and brain cancers. Additionally, we aim at transfering results of biomathematical model simulations into clinical practice e.g. by haematopoietic growth-factor opimization during cytotoxic chemotherapy and optimization of EPO applications in chronic kidney disease.
The ...
Programme: This Project is not associated with a Programme
Public web page: http://www.imise.uni-leipzig.de/en/Groups/GenStat/
Start date: 1st Jan 2013
A meta-analysis of genome-wide associations for serum vaspin from six independent cohorts (N = 7446) was conducted. The data show that serum vaspin is strongly determined by genetic variants within vaspin.
This study belongs to the publication: https://doi.org/10.1002/oby.23882
Submitter: Katrin Horn
Investigation: OMICS Investigations
Resources: Summary Statistics
Study type: Genetic study
Submitter: Katrin Horn
Investigation: OMICS Investigations
Resources: Gene Expression data, LIFE-Adult EPIC data
Study type: Not specified
Summary statistics of Meta-GWAS results will be made available upon acceptance of our manuscript.
Submitter: Janne Pott
Investigation: OMICS Investigations
Resources: Summary Statistics
Study type: Genetic study
In our manuscript, we describe current procedures, tools, and results to create, compare and qualitatively assess the single-cell transcriptomes of the lung in three different species; human (Homo sapiens), hamster (Mesocricetus auratus), and mice (Mus musculus).
We make the analysis reproducible by publishing the R-based workflow on GitHub pulmonologists_interspecies_scRNA.
Here in the LHA, we provide the required scRNA-Seq
...
Submitter: Holger Kirsten
Investigation: OMICS Investigations
Resources: scRNA-Seq expression data as RDS Seurat file
Study type: Cell study
Genome-wide Association Meta-Analyses of four steroid hormones (progesterone, 17-OH-progesterone, androstenedione, and aldosterone) and the ratio of testosterone to estradiol. Summary statistics of GWAMA results will be made available upon acceptance of our manuscript.
Submitter: Janne Pott
Investigation: OMICS Investigations
Resources: No Resources
Study type: Genetic study
Genome-wide Association Meta-Analyses of 32 phytosterol traits reflecting resorption, cholesterol synthesis and esterification in six studies with up to 9,758 subjects Summary statistics of GWAMA results will be made available upon acceptance of our manuscript.
Submitter: Janne Pott
Investigation: OMICS Investigations
Resources: Summary Statistics - Phytosterols
Study type: Genetic study
Submitter: Janne Pott
Investigation: OMICS Investigations
Resources: Summary Statistics
Study type: Genetic study
We analysed if measuring PWV in different segments of the body leads to association with different genetic variants, as well as different heritability and different genetic correlation with other biological traits. Furthermore we searched for shared genetic architecture concerning PWV, blood pressure (BP) and coronary artery disease (CAD) and examined the causal relationship between PWV and BP.
Submitter: Janne Pott
Investigation: OMICS Investigations
Resources: Summary Statistic for PWV GWAS
Study type: Genetic study
We defined six operationalizations of CPB considering plaques in common carotid arteries, carotid bulb, and internal carotid arteries (maximal plaque area, mean plaque area, sum of plaque areas at all six regions, maximal degree of stenosis, mean degree of stenosis, and sum of stenosis at all six regions). Link to publication (PMID, DOI), Supplemental Figures and Tables, and Summary Statistics of GWAS will be made available upon acceptance of our manuscript.
Submitter: Janne Pott
Investigation: OMICS Investigations
Resources: Summary Statistics
Study type: Genetic study
Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)
Submitter: René Hänsel
Investigation: OMICS Investigations
Resources: Summary Statistics, Supplement Data
Study type: Genetic study
Summary Statistics used in publication
Submitter: Katrin Horn
Resource type: Genome Wide Association
Technology type: Technology Type
Investigation: OMICS Investigations
Study: GWAMA vaspin
Submitter: Katrin Horn
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: OMICS Investigations
To provide data input and result from a scRNA-Seq integration workflow
Submitter: Holger Kirsten
Resource type: Experimental Assay Type
Technology type: Technology Type
Investigation: OMICS Investigations
Submitter: Andreas Kühnapfel
Biological problem addressed: Genome Scale
Investigation: OMICS Investigations
Study: GWAS Body Scanner Measures
Submitter: Katrin Horn
Resource type: Gene Expression Profiling
Technology type: Technology Type
Investigation: OMICS Investigations
We are releasing the summary data from our GWAMA of PCSK9 levels, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.
Citation: tba
When using this data acknowledge the source as follows: 'Data on PCSK9 has been downloaded from https://www.health-atlas.de/data_files/551.'
For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) ...
Submitter: Janne Pott
Resource type: Experimental Assay Type
Technology type: SNP Array
Investigation: OMICS Investigations
Study: GWAMA PCSK9
We are releasing the summary data from our GWAMA of phytosterol traits, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.
Citation: tba
When using this data acknowledge the source as follows: 'Data on phytosterol X has been contributed by LIFE investigators and has been downloaded from https://www.health-atlas.de/assays/53.'
For any enquiries about ...
Submitter: Janne Pott
Resource type: Experimental Assay Type
Technology type: SNP Array
Investigation: OMICS Investigations
Study: GWAMA Phytosterole
Summary statistics from GWAS of baPWV, bfPWV, cfPWV All samples (adjusted for age, sex and log_sys)
These data is intended for research purposes only.
Citation: tbc
When using this data acknowledge the source as follows: 'Data on PWV has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/34'
For any enquiries about the datasets, please contact Michael Rode (michael.rode@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de) ...
Submitter: Michael Rode
Resource type: Genome Wide Association
Technology type: SNP Array
Investigation: OMICS Investigations
Study: GWAS Pulse Wave Velocity
We are releasing the summary data from our GWAS of carotid plaque burden traits, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.
Citation:
When using this data acknowledge the source as follows: 'Data on carotid plaque burden has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/31 '
For any ...
Submitter: Janne Pott
Resource type: Genome Wide Association
Technology type: SNP Array
Investigation: OMICS Investigations
Study: GWAS Carotid Plaque Burden
We are releasing the summary data from our meta-analyses of steroid hormones, to empower other researchers to examine variants or loci in which they are interested for association with these hormonal traits. These data are intended for research purposes only.
Citation: Pott et al. (2019) Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease. J Clin Endocrinol Metab 104: 5008–5023. PubMed ID: 31169883
When using this data acknowledge ...
Submitter: Janne Pott
Resource type: Genome Wide Association
Technology type: SNP Array
Investigation: OMICS Investigations
Study: GWAS Steroid Hormones
Abstract (Expand)
Authors: Carl Beuchel, Holger Kirsten, Uta Ceglarek, Markus Scholz
Date Published: 16th Nov 2020
Publication Type: Journal article
Abstract (Expand)
Authors: Michael Rode, Andrej Teren, Kerstin Wirkner, Katrin Horn, Holger Kirsten, Markus Loeffler, Markus Scholz, Janne Pott
Date Published: 13th Aug 2020
Publication Type: Journal article
Human Diseases: arteriosclerosis, arteriosclerotic cardiovascular disease
Abstract (Expand)
Authors: J. Pott, F. Beutner, K. Horn, H. Kirsten, K. Olischer, K. Wirkner, M. Loeffler, M. Scholz
Date Published: 30th May 2020
Publication Type: Journal article
Human Diseases: cardiovascular system disease, atherosclerosis
Abstract (Expand)
Authors: J. Pott, YJ. Bae, K. Horn, A. Teren, Andreas Kühnapfel, H. Kirsten, U. Ceglarek, Markus Löffler, J. Thiery, J. Kratzsch, Markus Scholz
Date Published: 6th Jun 2019
Publication Type: Not specified
Human Diseases: coronary artery disease
Abstract (Expand)
Authors: J. Pott, R. Burkhardt, F. Beutner, K. Horn, A. Teren, H. Kirsten, L. M. Holdt, G. Schuler, D. Teupser, M. Loeffler, J. Thiery, M. Scholz
Abstract (Expand)
Authors: R. Burkhardt, H. Kirsten, F. Beutner, L. M. Holdt, A. Gross, A. Teren, A. Tonjes, S. Becker, K. Krohn, P. Kovacs, M. Stumvoll, D. Teupser, J. Thiery, U. Ceglarek, M. Scholz
Abstract (Expand)
Authors: H. Kirsten, H. Al-Hasani, L. Holdt, A. Gross, F. Beutner, K. Krohn, K. Horn, P. Ahnert, R. Burkhardt, K. Reiche, J. Hackermuller, M. Loffler, D. Teupser, J. Thiery, M. Scholz
Date Published: 15th Aug 2015
Publication Type: Journal article
For our R-based workflow on GitHub pulmonologists_interspecies_scRNA, we here provide the processed resulting annotated integrated Seurat file.
References for original datasets :
Human Charité: Hocke A, Hönzke K, Obermayer B, Baumgardt M, Wyler E, Hippenstiel S, Mache C. Charité Berlin /Berlin Institute of Health. GEO accessions GSM5958267, GSM5958272, GSM5958283, GSM5958285
Human Travaglini et al.: published at ...
Input Files for Manuscript "A pulmonologist’s guide to perform and analyse cross-species single-lung-cell transcriptomic"
See https://github.com/GenStatLeipzig/pulmonologists_interspecies_scRNA for details.
Manuscript authored by:
Peter Pennitz1,2*, Holger Kirsten3*, Vincent D. Friedrich3,4, Emanuel Wyler5, Cengiz Goekeri1,2,6, Benedikt Obermayer7, Gitta A. Heinz8, Mir-Farzin Mashreghi8,9, Maren Büttner10,11 Jakob Trimpert12, Markus Landthaler5,13, Norbert Suttorp2, Andreas C. Hocke1,2, Stefan ...
Summary statistics from GWAMA of PCSK9 levels. These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using this data acknowledge the source as follows: 'Data on PCSK9 has been downloaded from https://www.health-atlas.de/data_files/551'
We make three data sets available:
- Containing statistics ...
Creator: Janne Pott
Submitter: Janne Pott
Data file type: Not specified
Human Diseases: atherosclerosis
Summary statistics from GWAMA of stigmasterol (stf_chf, free stigmasterol to free cholesterol; stt_cht, total stigmasterol to total cholesterol; stf_laf, free stigmasterol to free lanosterol; stt_laf, total stigmasterol to free lanosterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Summary statistics from GWAMA of stigmasterol (ste, esterified stigmasterol; stf, free stigmasterol; stt, total stigmasterol; stf_ste, free to esterified stigmasterol). These data are intended for research purposes only, and available upon publication. For any enquiries about the datasets, please contact Janne Pott (janne.pott@imise.uni-leipzig.de) or Markus Scholz (markus.scholz@imise.uni-leipzig.de).
Citation: tba
When using this data acknowledge the source as follows: 'Data on stigmasterol ...
Creators: Katrin Horn, Markus Scholz, Janne Pott
Submitter: Janne Pott
Data file type: Other OMICs Data
Creator: Katrin Horn
Submitter: Katrin Horn
Creator: Katrin Horn
Submitter: Katrin Horn
Creator: Katrin Horn
Submitter: Katrin Horn
Supplement Data for Publication including Supplement Material & Results (eQTL annotation, Mendelian Randomization (MR), further significant loci), Figures (correlation plot of steroid hormones, scatter plot of genetic effect sizes, regional association plots, scatter plots of MR) and Tables (Correlations, GWAS summary statistics, interaction tests, MR results)
Creator: Janne Pott
Submitter: René Hänsel
Projects: LHA - Leipzig Health Atlas, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, LIFE Heart, MMML - Molecular mechanisms in malignant lymphoma, GLA - German Lymphoma Alliance, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, e:Med, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, MMML-MYC-SYS, NLP4CR - Natural Language Processing for Clinical Research, Genetical Statistics and Systems Biology, SepNet - German Competence Network Sepsis, LIFE Child, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, GGN - German Glioma Network, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, CapSys - Systems Medicine of Community Acquired Pneumonia, ProstataCA, HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia, SMITH - Smart Medical Information Technology for Healthcare, Task Force COVID-19 Leipzig, NFDI4Health, POLAR - Polypharmacy, Drug Interactions, Risks, Management of health information systems, LivSys Transfer - Transfer of the LivSys in vitro system for hepatotoxicity into application, Project Test Demonstrator, Fundus photography as tool for analysis of eyes of subjects with diabetes, Clinical Trials Leipzig, NFDI4Health - TA3 Services, STOP-NUC, SCALE-TORT, EarlyAMDRate
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
https://orcid.org/0000-0001-8344-0658
Projects: LIFE Heart, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, SepNet - German Competence Network Sepsis, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, LIFE Child, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, LIFE Adult
Web page: https://www.uniklinikum-leipzig.de/einrichtungen/life
