With the knowledge achieved in this project new molecular classifiers will be identified to improve the diagnosis of this disease.
MMML-MYC-SYS is a interdisciplinary consortium where partners from clinical haemaoncological study groups, pathologists, geneticicts, cell biologists as well as mathematicians, statisticians and bioinformaticists have allied. The goal is to investigate the process of development of B-cell lymphoma under special consideration of mutation of MYC. MYC is known to support the development and growth of tumors. This consortium collected and evaluated comprehensive molecular-genetic data for this purpose. The formation and growth of the tumor is simulated and predicted through computer models.
Programme: This Project is not associated with a Programme
LHA ID: 7Q0CR2P54E-8
Funding codes:- BMBF
- FKZ 031 6166
Public web page: http://www.mmmlmycsys.de/
Human Diseases: Non-hodgkin lymphoma
Health Atlas - Local Data Hub/Leipzig PALs: Markus Löffler
Project Coordinators: No Project coordinators for this Project
Project start date: 1st Jan 2013
Related items
Abstract (Expand)
Authors: H. Loeffler-Wirth, M. Kreuz, L. Hopp, A. Arakelyan, A. Haake, S. B. Cogliatti, A. C. Feller, M. L. Hansmann, D. Lenze, P. Moller, H. K. Muller-Hermelink, E. Fortenbacher, E. Willscher, G. Ott, A. Rosenwald, C. Pott, C. Schwaenen, H. Trautmann, S. Wessendorf, H. Stein, M. Szczepanowski, L. Trumper, M. Hummel, W. Klapper, R. Siebert, M. Loeffler, H. Binder
Date Published: 30th Apr 2019
Publication Type: Not specified
Human Diseases: B-cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Burkitt lymphoma
PubMed ID: 31039827
Citation: Genome Med. 2019 Apr 30;11(1):27. doi: 10.1186/s13073-019-0637-7.
Abstract (Expand)
Authors: V. Cakir, H. Loeffler-Wirth, A. Arakelyan, H. Binder
DOI: 10.15761/BEM.1000115
Citation:
Abstract (Expand)
Authors: L. Hopp, L. Nersisyan, H. Loffler-Wirth, A. Arakelyan, H. Binder
PubMed ID: 26506391
Citation: Genes (Basel). 2015 Oct 21;6(4):1076-112. doi: 10.3390/genes6041076.
Abstract (Expand)
Authors: L. Hopp, H. Loffler-Wirth, H. Binder
Date Published: 7th Sep 2015
Publication Type: Not specified
Human Diseases: non-Hodgkin lymphoma, B-cell lymphoma
PubMed ID: 26371046
Citation: Genes (Basel). 2015 Sep 7;6(3):812-40. doi: 10.3390/genes6030812.
Abstract (Expand)
Authors: L. Hopp, K. Lembcke, H. Binder, H. Wirth
Date Published: 2nd Dec 2013
Publication Type: Not specified
Human Diseases: non-Hodgkin lymphoma, B-cell lymphoma
PubMed ID: 24833231
Citation: Biology (Basel). 2013 Dec 2;2(4):1411-37. doi: 10.3390/biology2041411.
We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for Burkitt's lymphoma was generated, and chromosomal abnormalities were detected with interphase fluorescence in situ hybridization and array-based comparative genomic hybridization.
Creator: Michael Hummel
Submitter: Christoph Beger
Data file type: Genomic Data
Human Diseases: B-cell lymphoma
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 873 biopsy specimens including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt’s lymphoma (BL), mixed FL/DLBCL lymphomas, primary mediastinal large B-cell lymphoma (PMBL), multiple myeloma (MM), IRF4-rearranged large cell lymphoma, MYC-negative high-grade B-cell lymphomas with Chr. 11q aberration pattern (mnBLL-11q), and Mantle cell lymphoma (MCL).
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Based on the assumption that molecular mechanisms involved in cancerogenesis are characterized by groups of coordinately expressed genes, we developed and validated a novel method for analyzing transcriptional data called Correlated Gene Set Analysis (CGSA). Using 50 extracted gene sets we identified three different profiles of tumors in a cohort of 364 Diffuse large B-cell (DLBCL) and related mature aggressive B-cell lymphomas other than Burkitt lymphoma. The first profile had high level of ...
Creator: Maciej Rosolowski
Submitter: Christoph Beger
Data file type: Transcriptomic Data
Human Diseases: diffuse large B-cell lymphoma
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
We present a transcriptome map of mature B-cell lymphomas that was obtained by analyzing expression data of 873 biopsy specimens including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt’s lymphoma (BL), mixed FL/DLBCL lymphomas, primary mediastinal large B-cell lymphoma (PMBL), multiple myeloma (MM), IRF4-rearranged large cell lymphoma, MYC-negative high-grade B-cell lymphomas with Chr. 11q aberration pattern (mnBLL-11q), and Mantle cell lymphoma (MCL) to describe their ...
Creator: Henry Löffler-Wirth
Submitters: Christoph Beger, Henry Löffler-Wirth
Data file type: SOM Data
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
We performed gene-expression analysis of 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A SOM was trained using molecular classification of specimen according to molecular Burkitt's Lymphoma score provided by Hummel et al.
Creator: Henry Löffler-Wirth
Submitters: Christoph Beger, Henry Löffler-Wirth
Data file type: SOM Data
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Projects: HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia, e:Med, Fundus photography as tool for analysis of eyes of subjects with diabetes, Clinical Trials Leipzig, NFDI4Health, NFDI4Health - TA3 Services, POLAR - Polypharmacy, Drug Interactions, Risks, STOP-NUC, SCALE-TORT, CapSys - Systems Medicine of Community Acquired Pneumonia, LHA - Leipzig Health Atlas, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, LIFE Child, GLA - German Lymphoma Alliance, MMML-MYC-SYS, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, MMML - Molecular mechanisms in malignant lymphoma, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, NLP4CR - Natural Language Processing for Clinical Research, LIFE Heart, ProstataCA, SepNet - German Competence Network Sepsis, Genetical Statistics and Systems Biology, GGN - German Glioma Network, Task Force COVID-19 Leipzig, SMITH - Smart Medical Information Technology for Healthcare, Management of health information systems, LivSys Transfer - Transfer of the LivSys in vitro system for hepatotoxicity into application, Project Test Demonstrator
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
![](/assets/logos/orcid_16x16-cb273c1ff10d304ce1b6108a172bfd1660561e7fd8133b083cd66ee0f4a0a944.png)
Roles: Technician
Expertise: Data Management, Data analysis, Python, Html
Projects: LIFE HNC - Head and Neck Cancer Group, LIFE - Leipzig Research Center for Civilization Diseases, LIFE Heart, MMML - Molecular mechanisms in malignant lymphoma, GLA - German Lymphoma Alliance, MMML-MYC-SYS, GGN - German Glioma Network
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
Projects: Genetical Statistics and Systems Biology, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, GLA - German Lymphoma Alliance, LIFE HNC - Head and Neck Cancer Group, LIFE - Leipzig Research Center for Civilization Diseases, MMML-MYC-SYS, LIFE Adult, MMML - Molecular mechanisms in malignant lymphoma, SepNet - German Competence Network Sepsis, HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia, e:Med, SMITH - Smart Medical Information Technology for Healthcare, LHA - Leipzig Health Atlas, POLAR - Polypharmacy, Drug Interactions, Risks, Task Force COVID-19 Leipzig, NFDI4Health
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig
Prof. Dr. Markus Löffler Universität Leipzig Institut für Medizinische Informatik, Statistik und Epidemiologie Härtelstraße 16-18 04107 Leipzig
Projects: Think different, imSAVAR - Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies, Vine Bioinformatics - grape genomics for Innovative viticulture, oBIG - omics Bioinformatics for Health, GLA - German Lymphoma Alliance, MMML-MYC-SYS, Leipzig Melanoma Studies, GGN - German Glioma Network, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, Task Force COVID-19 Leipzig, NFDI4Health, LHA - Leipzig Health Atlas
Institutions: University of Leipzig, Interdisciplinary Center for Bioinformatics (IZBI)
![](/assets/logos/orcid_16x16-cb273c1ff10d304ce1b6108a172bfd1660561e7fd8133b083cd66ee0f4a0a944.png)
Projects: MMML-MYC-SYS, GLA - German Lymphoma Alliance
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
Institut für Medizinische Informatik, Statistik und Epidemiologie Universität Leipzig Härtelstraße 16-18 04107 Leipzig
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_0060060
Definitions: A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma., OMIM mapping confirmed by DO. [LS].