Leipzig Human Glands Studies
OverviewLeipzig Human Glands project consists of studies of the Institute of the Veterinary Physiology (Leipzig University) and the Interdisciplinary Center for Bioinformatics (IZBI, Leipzig University). Spatially resolved transcriptome analyses of human glands (sebaceous gland, meibomian gland) where preformed in the frame of this undertaking.
Programme: European Union’s Horizon 2020
LHA ID: 8U40U7YQK1-1
Public web page: Not specified
Human Diseases: No Human Disease specified
Health Atlas - Local Data Hub/Leipzig PALs: No PALs for this Project
Project Coordinators: No Project coordinators for this Project
Project start date: 1st Jul 2023
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Meibomian glands (MGs), specialized sebaceous glands embedded in the eyelids, are an integral component of the ocular defense system, as their oily secretion product, meibum, is essential for protecting the eye surface. In spite of its importance for ocular health, the transcriptional changes that lead to meibum production by MG acinar cells (meibocytes) have not been characterized in a systematic way so far. By combining spatial transcriptomics (ST), pseudotime, and functional enrichment analysis, ...
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The lipid-secreting sebaceous glands (SG) are indispensable for maintaining skin structure and function, and may influence whole body’s energy metabolism. SG deregulation is also associated with a number of skin disorders, including but not limited to acne. Here, we exploit the high cellular resolution provided by sebaceous hyperplasia to spatially characterize the human SG transcriptional program. By integrating single-cell spatial transcriptomics, pseudotime analysis, RNA velocity, and functional ...
Creators: Maria Schmidt, Henry Löffler-Wirth, Hans Binder, Marlon Schneider
Submitter: Henry Löffler-Wirth
Data file type: Transcriptomic Data
Projects: Leipzig Melanoma Studies, GLA - German Lymphoma Alliance, MMML-MYC-SYS, GGN - German Glioma Network, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, Task Force COVID-19 Leipzig, NFDI4Health, LHA - Leipzig Health Atlas, Think different, imSAVAR - Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies, oBIG - omics Bioinformatics for Health, Vine Bioinformatics - grape genomics for Innovative viticulture, Leipzig Human Glands Studies
Institutions: University of Leipzig, Interdisciplinary Center for Bioinformatics (IZBI), Interdisciplinary Center for Bioinformatics (IZBI, Leipzig University)
https://orcid.org/0000-0001-8239-440X
Projects: Vine Bioinformatics - grape genomics for Innovative viticulture, Leipzig Human Glands Studies, imSAVAR - Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies
Web page: Not specified
