We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for Burkitt's lymphoma was generated, and chromosomal abnormalities were detected with interphase fluorescence in situ hybridization and array-based comparative genomic hybridization.
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MMML-MYC-SYS is a interdisciplinary consortium where partners from clinical haemaoncological study groups, pathologists, geneticicts, cell biologists as well as mathematicians, statisticians and bioinformaticists have allied. The goal is to investigate the process of development of B-cell lymphoma under special consideration of mutation of MYC. MYC is known to support the development and growth of tumors. This consortium collected and evaluated comprehensive molecular-genetic data for this purpose. ...
Programme: This Project is not associated with a Programme
Public web page: http://www.mmmlmycsys.de/
Start date: 1st Jan 2013
Organisms: Not specified
Human Diseases: non-Hodgkin lymphoma
B-cell lymphoma is the most frequent lymphoid neoplasia accounting for one third of all lymphomas. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) is the current treatment standard, leading to high cure rates especially in younger patients. Although the 3-year event-free survival is about 60% even for elderly patients between 60-80 years old, the remainder of patients eventually relapse and the majority die of their disease. The German Non-Hodgkin's Lymphoma Study ...
Programme: NHL
Public web page: https://www.dshnhl.org
Organisms: Homo sapiens
Human Diseases: non-Hodgkin lymphoma, B-cell lymphoma
Abstract (Expand)
Authors: V. Cakir, H. Loeffler-Wirth, A. Arakelyan, H. Binder
DOI: 10.15761/BEM.1000115
Citation:
Abstract (Expand)
Authors: C. Otto, R. Scholtysik, R. Schmitz, M. Kreuz, C. Becher, M. Hummel, A. Rosenwald, L. Trumper, W. Klapper, R. Siebert, R. Kuppers
Date Published: 30th Jun 2016
Publication Type: Journal article
Human Diseases: diffuse large B-cell lymphoma
PubMed ID: 27356265
Citation: Genes Chromosomes Cancer. 2016 Dec;55(12):932-943. doi: 10.1002/gcc.22391. Epub 2016 Jul 12.
Abstract (Expand)
Authors: S. M. Aukema, M. Kreuz, C. W. Kohler, M. Rosolowski, D. Hasenclever, M. Hummel, R. Kuppers, D. Lenze, G. Ott, C. Pott, J. Richter, A. Rosenwald, M. Szczepanowski, C. Schwaenen, H. Stein, H. Trautmann, S. Wessendorf, L. Trumper, M. Loeffler, R. Spang, P. M. Kluin, W. Klapper, R. Siebert
Date Published: 2nd Nov 2013
Publication Type: Not specified
Human Diseases: non-Hodgkin lymphoma, diffuse large B-cell lymphoma
PubMed ID: 24179151
Citation: Haematologica. 2014 Apr;99(4):726-35. doi: 10.3324/haematol.2013.091827. Epub 2013 Oct 31.
Abstract (Expand)
Authors: W. Klapper, M. Kreuz, C. W. Kohler, B. Burkhardt, M. Szczepanowski, I. Salaverria, M. Hummel, M. Loeffler, S. Pellissery, W. Woessmann, C. Schwanen, L. Trumper, S. Wessendorf, R. Spang, D. Hasenclever, R. Siebert
Date Published: 23rd Feb 2012
Publication Type: Not specified
Human Diseases: diffuse large B-cell lymphoma
PubMed ID: 22238326
Citation: Blood. 2012 Feb 23;119(8):1882-7. doi: 10.1182/blood-2011-10-388470. Epub 2012 Jan 11.
Projects: LHA - Leipzig Health Atlas, Onto-Med Research Group, SMITH - Smart Medical Information Technology for Healthcare, Task Force COVID-19 Leipzig, NFDI4Health, LIFE Child, LIFE - Leipzig Research Center for Civilization Diseases, Project Test Demonstrator
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Universitätsklinikum Leipzig, AöR, invalid
https://orcid.org/0000-0002-1166-0368Expertise: data integration, ruby, r, java, perl
Profile image source: Swen Reichhold
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_707
Synonyms: B-cell lymphocytic neoplasm
Definitions: A non-Hodgkin lymphoma that has_material_basis_in B cells.