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- Publications (19)
- Data files (7)
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- Presentations (1)
- People (5)
- Human Diseases (2)
During 2004 and 2012 the german cancer aid supported the german glioma network (GGN). The GGN is a consortium where university hospitals with clinical focus in neuro-oncology, reference centers for neuroradiology, neuropathology, molecular diagnostics and biometry cooperate. Thanks to the long-term support it was possible to build a network of competence centers for the treatment of brain tumors in Germany wich is characterized by a interdisciplinary collaboration of all specialist disciplines ...
Organisms: Not specified
Human Diseases: brain glioma, malignant glioma
Abstract (Expand)
Authors: H. Binder, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. T. W. Jones, S. M. Pfister, M. Kreuz, D. Gramatzki, E. Fortenbacher, B. Hentschel, M. Tatagiba, U. Herrlinger, H. Vatter, J. Matschke, M. Westphal, D. Krex, G. Schackert, J. C. Tonn, U. Schlegel, H. J. Steiger, W. Wick, R. G. Weber, M. Weller, M. Loeffler
PubMed ID: 31023364
Citation: Acta Neuropathol Commun. 2019 Apr 25;7(1):59. doi: 10.1186/s40478-019-0704-8.
Abstract (Expand)
Authors: L. Hopp, H. Loffler-Wirth, J. Galle, H. Binder
Date Published: 12th Jun 2018
Publication Type: Not specified
Human Diseases: glioblastoma multiforme
PubMed ID: 29888966
Citation: Epigenomics. 2018 Jun;10(6):745-764. doi: 10.2217/epi-2017-0140. Epub 2018 Jun 11.
Abstract (Expand)
Authors: J. Felsberg, B. Hentschel, K. Kaulich, D. Gramatzki, A. Zacher, B. Malzkorn, M. Kamp, M. Sabel, M. Simon, M. Westphal, G. Schackert, J. C. Tonn, T. Pietsch, A. von Deimling, M. Loeffler, G. Reifenberger, M. Weller
Date Published: 15th Nov 2017
Publication Type: Journal article
Human Diseases: brain glioblastoma multiforme
PubMed ID: 28855349
Citation: Clin Cancer Res. 2017 Nov 15;23(22):6846-6855. doi: 10.1158/1078-0432.CCR-17-0890. Epub 2017 Aug 29.
Abstract (Expand)
Authors: D. Gramatzki, P. Kickingereder, B. Hentschel, J. Felsberg, U. Herrlinger, G. Schackert, J. C. Tonn, M. Westphal, M. Sabel, U. Schlegel, W. Wick, T. Pietsch, G. Reifenberger, M. Loeffler, M. Bendszus, M. Weller
Date Published: 11th Apr 2017
Publication Type: Journal article
Human Diseases: brain glioblastoma multiforme
PubMed ID: 28298550
Citation: Neurology. 2017 Apr 11;88(15):1422-1430. doi: 10.1212/WNL.0000000000003809. Epub 2017 Mar 15.
Abstract (Expand)
Authors: R. Wang, R. W. van Leeuwen, A. Boers, H. G. Klip, T. de Meyer, R. D. Steenbergen, W. van Criekinge, A. G. van der Zee, E. Schuuring, G. B. Wisman
PubMed ID: 27738327
Citation: Oncotarget. 2016 Dec 6;7(49):80735-80750. doi: 10.18632/oncotarget.12598.
Abstract (Expand)
Authors: D. Mangani, M. Weller, E. Seyed Sadr, E. Willscher, K. Seystahl, G. Reifenberger, G. Tabatabai, H. Binder, H. Schneider
Date Published: 12th Jun 2016
Publication Type: Not specified
Human Diseases: glioblastoma multiforme
PubMed ID: 27286797
Citation: Neuro Oncol. 2016 Dec;18(12):1610-1621. doi: 10.1093/neuonc/now112. Epub 2016 Jun 10.
Abstract (Expand)
Authors: D. Gramatzki, P. Roth, J. Felsberg, S. Hofer, E. J. Rushing, B. Hentschel, M. Westphal, D. Krex, M. Simon, O. Schnell, W. Wick, G. Reifenberger, M. Weller
Date Published: 23rd Apr 2016
Publication Type: Journal article
Human Diseases: adult brain ependymoma
PubMed ID: 27108407
Citation: BMC Cancer. 2016 Apr 23;16:287. doi: 10.1186/s12885-016-2323-0.
Abstract (Expand)
Authors: M. Weller, R. G. Weber, E. Willscher, V. Riehmer, B. Hentschel, M. Kreuz, J. Felsberg, U. Beyer, H. Loffler-Wirth, K. Kaulich, J. P. Steinbach, C. Hartmann, D. Gramatzki, J. Schramm, M. Westphal, G. Schackert, M. Simon, T. Martens, J. Bostrom, C. Hagel, M. Sabel, D. Krex, J. C. Tonn, W. Wick, S. Noell, U. Schlegel, B. Radlwimmer, T. Pietsch, M. Loeffler, A. von Deimling, H. Binder, G. Reifenberger
PubMed ID: 25783747
Citation: Acta Neuropathol. 2015 May;129(5):679-93. doi: 10.1007/s00401-015-1409-0. Epub 2015 Mar 18.
Abstract (Expand)
Authors: E. Willscher, H. Loffler-Wirth, H. Binder, Lydia Hopp
Citation:
Abstract (Expand)
Authors: G. Reifenberger, R. G. Weber, V. Riehmer, K. Kaulich, E. Willscher, H. Wirth, J. Gietzelt, B. Hentschel, M. Westphal, M. Simon, G. Schackert, J. Schramm, J. Matschke, M. C. Sabel, D. Gramatzki, J. Felsberg, C. Hartmann, J. P. Steinbach, U. Schlegel, W. Wick, B. Radlwimmer, T. Pietsch, J. C. Tonn, A. von Deimling, H. Binder, M. Weller, M. Loeffler
PubMed ID: 24615357
Citation: Int J Cancer. 2014 Oct 15;135(8):1822-31. doi: 10.1002/ijc.28836. Epub 2014 Mar 28.
This workspace contains all data generated by the combiSOM analysis of patient-matched gene expression, DNA-methylation and copy number variation (CNV) of 121 lower grade glioma (LGG) specimen.
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed microarray-based genome- and transcriptome-wide molecular profiling of primary tumor samples from 137 patients with cerebral gliomas, 61 WHO grade II and 76 WHO grade III tumors.
Creators: Henry Löffler-Wirth, Markus Kreuz
Submitter: Christoph Beger
Data file type: Genomic Data
Human Diseases: brain glioma
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed Methylation profiling of primary tumor samples from 122 patients with cerebral gliomas with WHO grade II and grade III tumors.
Creators: Hans Binder, Markus Kreuz, Henry Löffler-Wirth
Submitter: Christoph Beger
Data file type: Methylation Data
Human Diseases: brain glioma
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed Methylation profiling of primary tumor samples from 122 patients with cerebral gliomas with WHO grade II and grade III tumors.
Creators: Hans Binder, Henry Löffler-Wirth, Markus Kreuz
Submitter: Christoph Beger
Data file type: Methylation Data
Human Diseases: brain glioma
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed microarray-based genome- and transcriptome-wide molecular profiling of primary tumor samples from 137 patients with cerebral gliomas, 61 WHO grade II and 76 WHO grade III tumors.
Creators: Hans Binder, Henry Löffler-Wirth
Submitter: Henry Löffler-Wirth
Data file type: SOM Data
Human Diseases: brain glioma
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
Progression free survival and overall survival of patients with brain tumors dependent on IDH1 mutation, methyltransferase (MGMT) methylation, age, WHO diagnosis and combinations of these factors.
Creator: Bettina Hentschel
Submitter: Christoph Beger
Data file type: Clinical Data
Human Diseases: brain glioma, brain glioblastoma multiforme
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
For this study, we screened prospectively recruited patients with a histopathological reference diagnosis of cerebral tumors of WHO grade II and III, known KPS at diagnosis, information on extent of resection by early postoperative neuroimaging, available frozen tissue specimens from the initial operation, and documented clinical outcome.
Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological ...
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
The platform is intended for visualization of expression- and mutation-driven changes in biological pathway activities in cancer datasets available in ICGC. The impact of somatic mutations on protein-protein interactions were calculated using Mechismo. Overall activity of biological pathway was evaluated using Pathway Signal Flow algorithm. The application provides interactive heatmaps for pathway output sink node activities and pathway images with mapped affected interactions and output node ...
Creators: Hans Binder, Siras Hakobyan
Submitter: Christoph Beger
Model type: Self-Organizing Map
Model format: R package
Environment: Shiny
Organism: Homo sapiens
Human Disease: cancer
Investigations: No Investigations
Studies: No Studies
Resources: No Resources
This markdown document demonstrates how to generate key data portrayal analyses and visualizations from a workspace created by the combiSOM package. The triple-omics SOM portrayal approach presented here combines patient-matched gene expression, DNA-methylation and copy number variation (CNV) of 121 lower grade glioma (LGG) specimen.
Creator: Henry Löffler-Wirth
Submitter: Henry Löffler-Wirth
Projects: GGN - German Glioma Network
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
Bettina Hentschel Contact Institution IMISE Härtelstr. 16-18 04107 Leipzig
Projects: LHA - Leipzig Health Atlas, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, LIFE Heart, MMML - Molecular mechanisms in malignant lymphoma, GLA - German Lymphoma Alliance, MMML Demonstrators - Molecular Mechanisms in Malignant Lymphomas - Demonstrators of Personalized Medicine, HaematoOpt - Individualized model-based managing of the next-cycle thrombopenia of CHOEP/CHOP treated patients based on platelets dynamics during the previous cycles, e:Med, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, MMML-MYC-SYS, NLP4CR - Natural Language Processing for Clinical Research, Genetical Statistics and Systems Biology, SepNet - German Competence Network Sepsis, LIFE Child, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, GGN - German Glioma Network, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, CapSys - Systems Medicine of Community Acquired Pneumonia, ProstataCA, HaematoSys - Systems biology of haematopoiesis and haematopoietic neoplasia, SMITH - Smart Medical Information Technology for Healthcare, Task Force COVID-19 Leipzig, NFDI4Health, POLAR - Polypharmacy, Drug Interactions, Risks, Management of health information systems, LivSys Transfer - Transfer of the LivSys in vitro system for hepatotoxicity into application, Project Test Demonstrator, Fundus photography as tool for analysis of eyes of subjects with diabetes, Clinical Trials Leipzig, NFDI4Health - TA3 Services, STOP-NUC, SCALE-TORT
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
https://orcid.org/0000-0001-8344-0658Roles: Technician
Expertise: Data Management, Data analysis, Python, Html
Projects: MMML - Molecular mechanisms in malignant lymphoma, GLA - German Lymphoma Alliance, LIFE Heart, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, MMML-MYC-SYS, GGN - German Glioma Network
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE)
Projects: Think different, imSAVAR - Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies, Vine Bioinformatics - grape genomics for Innovative viticulture, oBIG - omics Bioinformatics for Health, GLA - German Lymphoma Alliance, MMML-MYC-SYS, Leipzig Melanoma Studies, GGN - German Glioma Network, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, Task Force COVID-19 Leipzig, NFDI4Health, LHA - Leipzig Health Atlas
Institutions: University of Leipzig, Interdisciplinary Center for Bioinformatics (IZBI)
https://orcid.org/0000-0001-8239-440XTaxonomy URI: http://purl.obolibrary.org/obo/DOID_3070
Synonyms: Neuroglial tumor, glial cell tumor, malignant Neuroglial tumor, glioma, malignant
Definitions: Xref MGI. OMIM mapping confirmed by DO. [SN]., A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine.
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_0060108
Synonyms: lower grade glioma
Definitions: A brain cancer that has_material_basis_in glial cells.