Interactive Pathway Activity Analysis Platform Version 1
External LinkThe platform is intended for visualization of expression- and mutation-driven changes in biological pathway activities in cancer datasets available in ICGC. The impact of somatic mutations on protein-protein interactions were calculated using Mechismo. Overall activity of biological pathway was evaluated using Pathway Signal Flow algorithm. The application provides interactive heatmaps for pathway output sink node activities and pathway images with mapped affected interactions and output node activities.
LHA ID: 7QWM5X316P-7
1 item is associated with this Model:
Human Disease: Cancer
Model type: Self-Organizing Map
Model format: R package
Execution or visualisation environment: Shiny
Model image: No image specified
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Created: 20th May 2019 at 11:24
Last updated: 17th Dec 2021 at 10:12
Last used: 21st Dec 2024 at 10:10
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Version History
Version 1 Created 20th May 2019 at 11:24 by Christoph Beger
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During 2004 and 2012 the german cancer aid supported the german glioma network (GGN). The GGN is a consortium where university hospitals with clinical focus in neuro-oncology, reference centers for neuroradiology, neuropathology, molecular diagnostics and biometry cooperate. Thanks to the long-term support it was possible to build a network of competence centers for the treatment of brain tumors in Germany wich is characterized by a interdisciplinary collaboration of all specialist disciplines ...
Projects: LHA - Leipzig Health Atlas, Onto-Med Research Group, SMITH - Smart Medical Information Technology for Healthcare, Task Force COVID-19 Leipzig, NFDI4Health, LIFE Child, LIFE - Leipzig Research Center for Civilization Diseases, Project Test Demonstrator
Institutions: Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Universitätsklinikum Leipzig, AöR, invalid
https://orcid.org/0000-0002-1166-0368
Profile image source: Swen Reichhold
Projects: Leipzig Melanoma Studies, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, CapSys - Systems Medicine of Community Acquired Pneumonia, e:Med, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, oBIG - omics Bioinformatics for Health
Institutions: Interdisciplinary Center for Bioinformatics (IZBI)
https://orcid.org/0000-0002-2242-4678
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_162
Synonyms: malignant tumor , malignant neoplasm, primary cancer
Definitions: Updating out dated UMLS CUI., A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
