Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta-analyses.


Recently, diagnostic clinical and imaging criteria for primary progressive aphasia (PPA) have been revised by an international consortium (Gorno-Tempini et al. Neurology 2011;76:1006-14). The aim of this study was to validate the specificity of the new imaging criteria and investigate whether different imaging modalities [magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET)] require different diagnostic subtype-specific imaging criteria. Anatomical likelihood estimation meta-analyses were conducted for PPA subtypes across a large cohort of 396 patients: firstly, across MRI studies for each of the three PPA subtypes followed by conjunction and subtraction analyses to investigate the specificity, and, secondly, by comparing results across MRI vs. FDG-PET studies in semantic dementia and progressive nonfluent aphasia. Semantic dementia showed atrophy in temporal, fusiform, parahippocampal gyri, hippocampus, and amygdala, progressive nonfluent aphasia in left putamen, insula, middle/superior temporal, precentral, and frontal gyri, logopenic progressive aphasia in middle/superior temporal, supramarginal, and dorsal posterior cingulate gyri. Results of the disease-specific meta-analyses across MRI studies were disjunct. Similarly, atrophic and hypometabolic brain networks were regionally dissociated in both semantic dementia and progressive nonfluent aphasia. In conclusion, meta-analyses support the specificity of new diagnostic imaging criteria for PPA and suggest that they should be specified for each imaging modality separately.

PubMed ID: 26901360

Projects: LIFE Adult

Publication type: Not specified

Journal: Eur J Neurol

Human Diseases: Aphasia

Citation: Eur J Neurol. 2016 Apr;23(4):704-12. doi: 10.1111/ene.12902. Epub 2016 Feb 22.

Date Published: 23rd Feb 2016

Registered Mode: by PubMed ID

Authors: S. Bisenius, J. Neumann, M. L. Schroeter

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Views: 2333

Created: 10th May 2019 at 13:51

Last updated: 7th Dec 2021 at 17:58

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