Summary statistics of a genome-wide association meta-analysis (GWAMA) of cholesterol precursors

Motivation:

Investigate genetic basis of cholesterol precursors lanosterol and desmosterol as intermediate phenotypes and the relation to coronary artery disease.

Summary

Summary statistics for genetic associations with cholesterol precursors. Investigated were traits related to lanosterol, desmosterol, and cholesterol. Summary statistics are formatted in the GWAS catalog format.

Publication

Förster et al. A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol. EBioMedicine 124, 106144 (2026). https://doi.org/10.1016/j.ebiom.2026.106144

File name description

Zoosterols are coded as a three letter code. The first two letters indicate analysed zoosterol.

ch: cholesterol
de: desmosterol
la: lanosterol

The third letter indicates esterification status.

f: free (unesterified)
e: esterified
t: total

Ratio traits are represented by the two respective zoosterols separated by an underscore.

Column descriptions

chromosome: chromosome of the variant
base_pair_location: bp position of the variant (in hg19 coordinates)
effect_allele: effect allele i.e. the allele to which the genetic effect refers to
other_allele: other allele
beta: genetic effect estimate
standard_error: standard error of the genetic effect
effect_allele_frequency: n-weighted frequency of the effect allele
p_value: two-sided p-value for the association of a variant
variant_id: ID for usage in meta-analysis
rs_id: rsID
info: imputation info score
n: total sample size of all studies combined
n_stud: number of studies where variant is present
I2: heterogeneity I^2
direction: effect direction of individual studies