Age and cellular composition influence overall survival in a collective of non-immunocompromised patients with EBV-positive diffuse large B-cell lymphoma from a German lymphoma center.


We investigated 41 diffuse large B-cell lymphomas (DLBCL) diagnosed at one center harboring >/=50% of latently Epstein-Barr virus (EBV)-infected neoplastic cells occurring in 34 patients aged >/=50 years and in 7 patients younger than 50 years in the absence of any known immunodeficiency for the expression patterns of EBV latent and immediate-early proteins, for the differentiation stage of the neoplastic cells, the presence of cytogenetic alterations and a possible co-infection with the human herpes virus (HHV)-8. Here, we show that EBV-positive DLBCLs rarely arise from naive and more frequently from post-germinal center B-cells that often contain crippling immunoglobulin gene mutations. Most of the lymphomas did not exhibit breaks in the BCL2, BCL6, and MYC genes and none of the cases investigated contained HHV-8 sequences. Patients aged <50 years performed better than older ones while in patients aged >/=50 years only the cellular composition had an impact on overall survival.

PubMed ID: 27122390

Projects: GLA - German Lymphoma Alliance

Publication type: Not specified

Journal: Leuk Lymphoma

Human Diseases: Diffuse large b-cell lymphoma

Citation: Leuk Lymphoma. 2016 Dec;57(12):2791-2803. doi: 10.3109/10428194.2016.1169406. Epub 2016 Apr 27.

Date Published: 29th Apr 2016

Registered Mode: by PubMed ID

Authors: K. Johrens, R. U. Trappe, D. Lenze, M. Pfreundschuh, M. Ziepert, M. Hummel, I. Anagnostopoulos

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Created: 17th Apr 2019 at 13:03

Last updated: 7th Dec 2021 at 17:58

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