GWAS Carotid Plaque Burden
The primary goal of this study was to identify genetic loci associated with carotid plaque burden (CPB) and to examine potential sex-specific genetic effects on plaque sizes. In a secondary analysis, we evaluated known genetic CAD and carotid plaque loci for association with our CPB traits to check for a genetic overlap with these traits.
We defined six operationalizations of CPB considering plaques in common carotid arteries, carotid bulb, and internal carotid arteries (maximal plaque area, mean plaque area, sum of plaque areas at all six regions, maximal degree of stenosis, mean degree of stenosis, and sum of stenosis at all six regions). Link to publication (PMID, DOI), Supplemental Figures and Tables, and Summary Statistics of GWAS will be made available upon acceptance of our manuscript.
LHA ID: 81JHC9GY6E-6
Projects: Genetical Statistics and Systems Biology, LIFE Adult, LIFE Heart
Study position:
Study type: Genetic study
Export PNG
Download
Creators and Submitter
Views: 2756
Created: 24th Mar 2020 at 08:24
Last updated: 27th Mar 2020 at 14:00
Related items
The LIFE-Heart study recruited 7,000 patients with suspected coronary heart disease, manifest heart disease or myocardial infarction. All patients received coronary angiography so that the vascular status in the heart is precisely known. In principle, this examination is not feasible in population-related studies. In addition, the patients were thoroughly examined with regard to the general vascular status and the health of the cardiovascular system. Extensive environmental factors were recorded. ...
Programme: LIFE Management Cluster
Public web page: http://life.uni-leipzig.de/
Start date: 1st Jan 2009
Goal of the Leipzig Research Center for Civilization Diseases (LIFE) is the investigation of civilization diseases like depression, diabetes, allergies or cardiovascular diseases. For this purpose we collect as much data as possible regarding health and living conditions of the population in Leipzig and provide these data for scientists of the University of Leipzig and other research institutions.
Programme: LIFE Management Cluster
Public web page: http://life.uni-leipzig.de/
Start date: 1st Jan 2009
This population-based study examined 10,000 participants randomly selected from the Leipzig population (2011 to 2014). A follow-up is to be carried out from 2017 - 2020. The study mainly included people aged between 40 and 79. All participants underwent a 6-hour study program and people over 60 years of age were invited two more times to in-depth study of cognition and depression and the brain (MRI, EEG). Extensive measurements of genome, metabolome and transcriptome are available. The LIFE-ADULT ...
Programme: LIFE Management Cluster
Public web page: http://life.uni-leipzig.de/en/adults/life_adult.html
Start date: 1st Jan 2009
The group is interested in omic-level studies including the genome, methylome, transcriptome, and metabolome of the general population as well as of various diseases including cardiovascular diseases, pneumonia, sepsis, obesity, and brain cancers. Additionally, we aim at transfering results of biomathematical model simulations into clinical practice e.g. by haematopoietic growth-factor opimization during cytotoxic chemotherapy and optimization of EPO applications in chronic kidney disease.
The ...
Programme: This Project is not associated with a Programme
Public web page: http://www.imise.uni-leipzig.de/en/Groups/GenStat/
Start date: 1st Jan 2013
Resutls of different OMICS-level using LIFE Adult and LIFE Heart data are presented (Publications, Supplemental Data, & Summary Statistics).
Submitter: René Hänsel
Studies: DNA methylation patterns reflect individual lifestyle independent from o..., GWAMA PCSK9, GWAMA Phytosterole, GWAMA Steroid hormones, GWAMA vaspin, GWAS Body Scanner Measures, GWAS Carotid Plaque Burden, GWAS Pulse Wave Velocity, GWAS Steroid Hormones, scRNA-Seq across species for pulmonologists
Resources: Gene Expression data, LIFE-Adult EPIC data, Summary Statistic for PWV GWAS, Summary Statistics, Summary Statistics, Summary Statistics, Summary Statistics, Summary Statistics, Summary Statistics - Phytosterols, Supplement Data, scRNA-Seq expression data as RDS Seurat file
We are releasing the summary data from our GWAS of carotid plaque burden traits, pending on acceptance of our publication, to empower other researchers to examine variants or loci in which they are interested for associations. These data are intended for research purposes only.
Citation:
When using this data acknowledge the source as follows: 'Data on carotid plaque burden has been contributed by LIFE-Adult investigators and has been downloaded from https://www.health-atlas.de/assays/31 '
For any ...
Submitter: Janne Pott
Resource type: Genome Wide Association
Technology type: SNP Array
Investigation: OMICS Investigations
Study: GWAS Carotid Plaque Burden
Abstract (Expand)
Authors: J. Pott, F. Beutner, K. Horn, H. Kirsten, K. Olischer, K. Wirkner, M. Loeffler, M. Scholz
Date Published: 30th May 2020
Publication Type: Journal article
Human Diseases: cardiovascular system disease, atherosclerosis
Abstract (Expand)
Authors: J. Pott, R. Burkhardt, F. Beutner, K. Horn, A. Teren, H. Kirsten, L. M. Holdt, G. Schuler, D. Teupser, M. Loeffler, J. Thiery, M. Scholz
Summary statistics from GWAS of CPS_mean for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on mean degree of stenosis has been contributed by LIFE-Adult investigators and has been downloaded ...
Summary statistics from GWAS of CPS_sum for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on sum of stenosis has been contributed by LIFE-Adult investigators and has been downloaded from ...
Summary statistics from GWAS of CPS_max for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on maximal degree of stenosis has been contributed by LIFE-Adult investigators and has been downloaded ...
Summary statistics from GWAS of CPA_mean for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on mean area of detected plaques has been contributed by LIFE-Adult investigators and has been downloaded ...
Summary statistics from GWAS of CPA_sum for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on sum of plaque areas has been contributed by LIFE-Adult investigators and has been downloaded from ...
Summary statistics from GWAS of CPA_max for
- all samples (adjusted for age and sex)
- men only (adjusted for age)
- women only (adjusted for age)
These data are intended for research purposes only.
Citation: Pott et al. (2020) Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men. PLOS ONE. PubMed ID: 32469969
When using this data acknowledge the source as follows: 'Data on area of the largest plaque detected has been contributed by LIFE-Adult investigators and has been ...
https://orcid.org/0000-0002-5983-5331
Projects: LIFE Heart, LIFE - Leipzig Research Center for Civilization Diseases, LIFE HNC - Head and Neck Cancer Group, SepNet - German Competence Network Sepsis, GC-HNPCC - German Consortium for Hereditary Non-Polyposis Colorectal Cancer, LIFE Child, GC-HBOC - German Consortium for Hereditary Breast and Ovarian Cancer, LIFE Adult
Web page: https://www.uniklinikum-leipzig.de/einrichtungen/life
