Details
Related items

SMARTE-R-CHOP-14

No description specified

LHA ID: 7WEYH205H8-3

Projects: GLA - German Lymphoma Alliance

Investigation position:

Help

Tree Split Graph

Export PNG

Click below to download a copy of the image

Download

Creators and Submitter

Creator

Marita Ziepert

Submitter

René Hänsel

Activity

Views: 2192

Created: 16th May 2019 at 14:03

Last updated: 16th May 2019 at 14:03

Related items

Projects (1)
Studies (1)
Resources (2)
Publications (2)
Data files (5)
People (2)
Programmes (1)

GLA - German Lymphoma Alliance

B-cell lymphoma is the most frequent lymphoid neoplasia accounting for one third of all lymphomas. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) is the current treatment standard, leading to high cure rates especially in younger patients. Although the 3-year event-free survival is about 60% even for elderly patients between 60-80 years old, the remainder of patients eventually relapse and the majority die of their disease. The German Non-Hodgkin's Lymphoma Study ...

Programme: NHL

Public web page: https://www.dshnhl.org

Organisms: Homo sapiens

Human Diseases: non-Hodgkin lymphoma, B-cell lymphoma

SMARTE-R-CHOP-14

GLA - German Lymphoma Alliance

All creators

Marita Ziepert

No description specified

Submitter: René Hänsel

Investigation: SMARTE-R-CHOP-14

Resources: SMARTE-R-CHOP-14 metadata, SMARTE-R-CHOP-14 trial data

Study type: Not specified

Snapshots: No snapshots

Created: 17th Apr 2019 at 12:29, Last updated: 16th May 2019 at 14:04

SMARTE-R-CHOP-14 trial data

GLA - German Lymphoma Alliance

All creators

Marita Ziepert

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival) Sample Size: 189

Submitter: René Hänsel

Resource type: Experimental Assay Type

Technology type: Technology Type

Investigation: SMARTE-R-CHOP-14

Study: SMARTE-R-CHOP-14

Human Diseases: B-cell lymphoma

Data files: SMARTE-R-CHOP-14 trial data-CSV, SMARTE-R-CHOP-14 trial data-ODM, SMARTE-R-CHOP-14 trial data-SPSS

Snapshots: No snapshots

Created: 16th May 2019 at 16:08, Last updated: 29th Oct 2019 at 10:59

SMARTE-R-CHOP-14 metadata

GLA - German Lymphoma Alliance

All creators

Marita Ziepert

Demographics, reference pathology diagnosis, Outcome (Event-free survival, Progression-free survival, Overall survival) Sample Size: 189

Submitter: René Hänsel

Resource type: Experimental Assay Type

Technology type: Technology Type

Investigation: SMARTE-R-CHOP-14

Study: SMARTE-R-CHOP-14

Human Diseases: B-cell lymphoma

Data files: SMARTE-R-CHOP-14 metadata-ODM, SMARTE-R-CHOP-14 metadata-XLSX

Snapshots: No snapshots

Created: 16th May 2019 at 16:08, Last updated: 29th Oct 2019 at 10:58

CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP.

GLA - German Lymphoma Alliance

(Show All)

All authors

Samira Zeynalova

Marita Ziepert

Markus Löffler

Abstract (Expand)

PURPOSE: To develop and validate a risk score for relapse in the CNS in patients with diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: A total of 2,164 patients (18 to 80 years old) with … aggressive B-cell lymphomas (80% DLBCL) treated with rituximab and CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone)-like chemotherapy, who were enrolled in studies from the German High-Grade Non-Hodgkin Lymphoma Study Group and the MabThera International Trial, were analyzed for occurrence of relapse/progression in the CNS. The resulting risk model was validated in an independent data set of 1,597 patients with DLBCL identified in the British Columbia Cancer Agency Lymphoid Cancer database. RESULTS: The risk model consists of the International Prognostic Index (IPI) factors in addition to involvement of kidneys and/or adrenal glands (CNS-IPI). In a three-risk group model, the low-risk group (46% of all patients analyzed), the intermediate-risk group (41%), and the high-risk group (12%) showed 2-year rates of CNS disease of 0.6% (CI, 0% to 1.2%), 3.4% (CI, 2.2% to 4.4%), and 10.2% (CI, 6.3% to 14.1%), respectively. Patients from the validation British Columbia Cancer Agency data set showed similar rates of CNS disease for low-risk (0.8%; CI, 0.0% to 1.6%), intermediate-risk (3.9%; CI, 2.3% to 5.5%), and high-risk (12.0%; CI, 7.9% to 16.1%) groups. CONCLUSION: The CNS-IPI is a robust, highly reproducible tool that can be used to estimate the risk of CNS relapse/progression in patients with DLBCL treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy. Close to 90% of patients with DLBCL belong to the low- and intermediate-risk groups and have a CNS relapse risk < 5%; they may be spared any diagnostic and therapeutic intervention. In contrast, those in the high-risk group have a > 10% risk of CNS relapse and should be considered for CNS-directed investigations and prophylactic interventions.

Authors: N. Schmitz, S. Zeynalova, M. Nickelsen, R. Kansara, D. Villa, L. H. Sehn, B. Glass, D. W. Scott, R. D. Gascoyne, J. M. Connors, M. Ziepert, M. Pfreundschuh, M. Loeffler, K. J. Savage