Alcohol consumption is positively associated with fasting serum ghrelin in non-dependent adults Trial Data
Version 1

BACKGROUND:Animal experiments and studies in alcohol dependent patients indicate that ghrelin signaling in the brain is causally involved in the regulation of alcohol reward and intake. Increasing ghrelin levels enhances alcohol craving and intake, blocking ghrelin receptors abolishes these effects. If ghrelin is also involved in non-dependent alcohol consumption in humans, though, remains unknown. The aim was therefore to investigate the relationship between ghrelin serum levels and alcohol consumption in a large population-based sample. METHODS:Total ghrelin was determined after an overnight fast in 1666 subjects participating in a population-based cross-sectional study ('LIFE') including 10,000 adults. 1521 subjects were included in this analysis. Alcohol consumption was assessed using a food frequency questionnaire (FFQ). Multiple linear regression analyses and extreme group comparisons testing for statistical differences of alcohol consumption between the highest and lowest quartile according to ghrelin levels were performed. RESULTS:Alcohol consumption was positively associated with serum ghrelin; total sample: β = 0.003, p = 0.002; men: β = 0.005, p = 0.023; women: β = 0.002, p = 0.007, adjusted for age, BMI and smoking status. Mean alcohol consumption in men/women belonging to the highest quartile of serum ghrelin levels (men: 21.5 (21.1) g/day; women: 7.5 (11.4) g/day) was considerably higher than in those belonging to the lowest quartile: men: 16.5 (19.3) g/day p < 0.002; women: 4.59 (10.7) g/day p = 0.0001 CONCLUSION:This is the first study showing that alcohol consumption is positively associated with serum ghrelin in a population-based sample. The study provides an initial indication that ghrelin is also involved in the regulation of alcohol consumption in non-dependent subjects.


Filename: PV0358_Ghrelin_N1521_kurz.xlsx  Download

Format: Spreadsheet

Size: 110 KB

Data file type: Clinical Data

Human Diseases: No Human Disease specified

help Creators and Submitter

Views: 2430   Downloads: 55

Created: 11th Oct 2019 at 09:53

Last updated: 28th Jan 2022 at 15:21

Last used: 25th May 2024 at 19:40

help Tags

This item has not yet been tagged.

help Attributions


Version History

Version 1 Created 11th Oct 2019 at 09:53 by René Hänsel

No revision comments

Powered by
Copyright © 2008 - 2021 The University of Manchester and HITS gGmbH
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig

By continuing to use this site you agree to the use of cookies