Projects

Background Single-cell RNA sequencing (scRNAseq) has been widely applied to dissect cellular heterogeneity in normal and diseased skin. Sebaceous glands, essential skin components with established functions in maintaining skin integrity and emerging roles in systemic energy metabolism, have been largely neglected in scRNAseq studies. Methods Departing from mouse and human skin scRNAseq datasets, we identified gene sets expressed especially in sebaceous glands with the open-source R-package oposSOM. ...

The study employed high quality non-mydriatic (i.e. pupil dilation is not required) fundus photography (FP) (Oculus Nidek AFC-230, 45 FOV) and a infra-red reflectance (IR) en face image obtained by scanning laser ophthalmoscope (SLO) (Heidelberg Spectralis, 30 FOV) to produce representative images of the retina and optic nerve. In order to prove the scale invariance property of tortuosity metrics, ophthalmological photographs from 18 subjects, both eyes, were randomly extracted from the ...

Generating and evaluating synthetic data in the medical domain. The synthetic data could be tabular or image.

Mice RPKM count data as applied in oposSOM. The gene cluster A-H introduced in this publication.

Coordinating investigators Prof. Dr. Jan C. Simon Prof. Dr. Regina Treudler Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig

Sponsor Universität Leipzig Ritterstr. 26, 04109 Leipzig

EudraCT: 2009-011737-27