Parkinson's disease

Details about this human disease

Synonyms (2)

Parkinson disease, paralysis agitans


Definitions (2)

A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions., Xref MGI. OMIM mapping confirmed by DO. [SN].


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Related items

Systems Medicine of Mitochondrial Parkinson’s Disease (SysMedPD)

The Systems Medicine of Mitochondrial Parkinson’s Disease (SysMedPD) study was initiated by an international consortium to contribute to the elucidation of mitochondrial underpinnings of Parkinson's Disease (PD).

Programme: This Project is not associated with a Programme

Public web page: http://www.sysmedpd.eu

Clinical data
Systems Medicine of Mitochondrial Parkinson’s Disease (SysMedPD)

Clinical characteristics of Parkinson's Disease patients and healthy controls

Submitter: Silke Szymczak

Resource type: Experimental Assay Type

Technology type: Technology Type

Investigation: Systems Medicine of Mitochondrial Parkinson’s D...

Study: SysMedPD metabolomics study

Metabolomics data
Systems Medicine of Mitochondrial Parkinson’s Disease (SysMedPD)

Targeted metabolomics data from blood samples using five different platforms (amines, acylcarnitines, organic acids, signaling lipids and lididomics)

Submitter: Silke Szymczak

Resource type: Metabolite Profiling

Technology type: Mass Spectrometry

Investigation: Systems Medicine of Mitochondrial Parkinson’s D...

Study: SysMedPD metabolomics study

Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease: Indications of a principal role of the brainstem.
LIFE Adult

Abstract (Expand)

During implantation of deep-brain stimulation (DBS) electrodes in the target structure, neurosurgeons and neurologists commonly observe a "microlesion effect" (MLE), which occurs well before … initiating subthalamic DBS. This phenomenon typically leads to a transitory improvement of motor symptoms of patients suffering from Parkinson's disease (PD). Mechanisms behind MLE remain poorly understood. In this work, we exploited the notion of ranking to assess spontaneous brain activity in PD patients examined by resting-state functional magnetic resonance imaging in response to penetration of DBS electrodes in the subthalamic nucleus. In particular, we employed a hypothesis-free method, eigenvector centrality (EC), to reveal motor-communication-hubs of the highest rank and their reorganization following the surgery; providing a unique opportunity to evaluate the direct impact of disrupting the PD motor circuitry in vivo without prior assumptions. Penetration of electrodes was associated with increased EC of functional connectivity in the brainstem. Changes in connectivity were quantitatively related to motor improvement, which further emphasizes the clinical importance of the functional integrity of the brainstem. Surprisingly, MLE and DBS were associated with anatomically different EC maps despite their similar clinical benefit on motor functions. The DBS solely caused an increase in connectivity of the left premotor region suggesting separate pathophysiological mechanisms of both interventions. While the DBS acts at the cortical level suggesting compensatory activation of less affected motor regions, the MLE affects more fundamental circuitry as the dysfunctional brainstem predominates in the beginning of PD. These findings invigorate the overlooked brainstem perspective in the understanding of PD and support the current trend towards its early diagnosis.

Authors: S. Holiga, K. Mueller, H. E. Moller, D. Urgosik, E. Ruzicka, M. L. Schroeter, R. Jech

Date Published: 29th Oct 2015

Publication Type: Not specified

Human Diseases: Parkinson's disease

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