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Leipzig Human Glands project consists of studies of the Institute of the Veterinary Physiology (Leipzig University) and the Interdisciplinary Center for Bioinformatics (IZBI, Leipzig University). Spatially resolved transcriptome analyses of human glands (sebaceous gland, meibomian gland) where preformed in the frame of this undertaking.
Organisms: Not specified
The cultivated grape (Vitis vinifera) has become the world’s leading fruit crop. Grape is unique not only because it is a major global perennial crop but also for its historical and cultural connections with the development of humans. One of the main challenges for viticulture is to sustainably maintain the production of high-quality grape varieties in the face of climate change. Current models predict an increasing disease pressure for grapes, mainly because of warmer and partly drier conditions. ...
Programme: European Union’s Horizon 2020
Public web page: https://www.fast.foundation/en/program/847/2022/new_tab/6586/6677
Organisms: Not specified
The vision of Immune Safety Avatar (imSAVAR) is to develop a platform for integrated nonclinical assessments of immunomodulatory therapy safety and efficacy.The imSAVAR is an Innovative Medicines Initiative funded project that aims to develop a standard for integrated nonclinical safety overviews for immune-modulatory investigational new drugs (IND) and clinical trial applications (CTA).Our imSAVAR platform will improve the prediction of the transferability of safety and efficacy of immunomodulators ...
Programme: European Union’s Horizon 2020
Public web page: https://imsavar.eu/
Organisms: Not specified
Abstract (Expand)
Authors: H. Loeffler-Wirth, M. Rade, A. Arakelyan, M. Kreuz, M. Loeffler, U. Koehl, K. Reiche, H. Binder
Date Published: 17th Oct 2022
Publication Type: Journal article
PubMed ID: 36248848
Citation: Front Immunol. 2022 Sep 28;13:994885. doi: 10.3389/fimmu.2022.994885. eCollection 2022.
Meibomian glands (MGs), specialized sebaceous glands embedded in the eyelids, are an integral component of the ocular defense system, as their oily secretion product, meibum, is essential for protecting the eye surface. In spite of its importance for ocular health, the transcriptional changes that lead to meibum production by MG acinar cells (meibocytes) have not been characterized in a systematic way so far. By combining spatial transcriptomics (ST), pseudotime, and functional enrichment analysis, ...
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The lipid-secreting sebaceous glands (SG) are indispensable for maintaining skin structure and function, and may influence whole body’s energy metabolism. SG deregulation is also associated with a number of skin disorders, including but not limited to acne. Here, we exploit the high cellular resolution provided by sebaceous hyperplasia to spatially characterize the human SG transcriptional program. By integrating single-cell spatial transcriptomics, pseudotime analysis, RNA velocity, and functional ...
Creators: Maria Schmidt, Henry Löffler-Wirth, Hans Binder, Marlon Schneider
Submitter: Henry Löffler-Wirth
Data file type: Transcriptomic Data
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Projects: Leipzig Melanoma Studies, GLA - German Lymphoma Alliance, MMML-MYC-SYS, GGN - German Glioma Network, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, Task Force COVID-19 Leipzig, NFDI4Health, LHA - Leipzig Health Atlas, Think different, imSAVAR - Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies, oBIG - omics Bioinformatics for Health, Vine Bioinformatics - grape genomics for Innovative viticulture, Leipzig Human Glands Studies
Institutions: University of Leipzig, Interdisciplinary Center for Bioinformatics (IZBI), Interdisciplinary Center for Bioinformatics (IZBI, Leipzig University)
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