Leipzig Melanoma Studies
OverviewThe Leipzig Melanoma Studies project consists of studies of the Department of Dermatology, Venereology and Allergology (Leipzig University), Interdisciplinary Center for Bioinformatics (IZBI, Leipzig University) and the Max Planck Institute for Evolutionary Anthropology Leipzig. Single cell transcriptome analyses of melanoma cases and cultures where preformed in the studies.
Programme: This Project is not associated with a Programme
LHA ID: 7QFYTCQMN4-6
Public web page: Not specified
Human Diseases: Melanoma
Health Atlas - Local Data Hub/Leipzig PALs: Hans Binder
Project Coordinators: No Project coordinators for this Project
Project start date: 1st Jan 2016
Related items
Abstract (Expand)
Authors: S. Hakobyan, H. Loeffler-Wirth, A. Arakelyan, H. Binder, M. Kunz
Date Published: 2nd Jul 2021
Publication Type: Journal article
Abstract (Expand)
Authors: M. Kunz, H. Loffler-Wirth, M. Dannemann, E. Willscher, G. Doose, J. Kelso, T. Kottek, B. Nickel, L. Hopp, J. Landsberg, S. Hoffmann, T. Tuting, P. Zigrino, C. Mauch, J. Utikal, M. Ziemer, H. J. Schulze, M. Holzel, A. Roesch, S. Kneitz, S. Meierjohann, A. Bosserhoff, H. Binder, M. Schartl
Abstract (Expand)
Authors: H. Loeffler-Wirth, H. Binder, E. Willscher, T. Gerber, M. Kunz
Abstract (Expand)
Authors: J. G. Camp, K. Sekine, T. Gerber, H. Loeffler-Wirth, H. Binder, M. Gac, S. Kanton, J. Kageyama, G. Damm, D. Seehofer, L. Belicova, M. Bickle, R. Barsacchi, R. Okuda, E. Yoshizawa, M. Kimura, H. Ayabe, H. Taniguchi, T. Takebe, B. Treutlein
Abstract (Expand)
Authors: T. Gerber, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. Schadendorf, M. Schartl, U. Anderegg, G. Camp, B. Treutlein, H. Binder, M. Kunz
307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS wild type, BRAF mutant/NRAS wild type and BRAF wild type/NRAS mutant melanoma metastasis, respectively
Creators: Hans Binder, Henry Löffler-Wirth, Manfred Kunz
Submitter: Christoph Beger
Data file type: Genomic Data
Human Diseases: melanoma
DownloadA series of 80 samples from benign melanocytic nevi and primary melanoma samples were analyzed by RNA sequencing (RNA-seq) to identify transcriptomic changes underlying early melanoma development.
Recent technological advances in single-cell genomics make it possible to analyze cellular heterogeneity of tumor samples. Here, we applied single-cell RNA-seq to measure the transcriptomes of 307 single cells cultured from three biopsies of three different patients with a BRAF/NRAS wild type, BRAF mutant/NRAS wild type and BRAF wild type/NRAS mutant melanoma metastasis, respectively. Analysis based on self-organizing maps identified sub-populations defined by multiple gene expression modules ...
External LinkSingle-cell transcriptomics has been used for analysis of heterogeneous populations of cells during developmental processes and for analysis of tumor cell heterogeneity. More recently, analysis of pseudotime (PT) dynamics of heterogeneous cell populations has been established as a powerful concept to study developmental processes. Here we perform PT analysis of 3 melanoma short-term cultures with different genetic backgrounds to study specific and concordant properties of PT dynamics of selected ...
Contribute to hloefflerwirth/scrat development by creating an account on GitHub.
Creator: Henry Löffler-Wirth
Submitter: Henry Löffler-Wirth
Model type: Not specified
Model format: R package
Environment: Not specified
Projects: Leipzig Melanoma Studies, CAPSys - Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome, CapSys - Systems Medicine of Community Acquired Pneumonia, e:Med, HNPCC-Sys - Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome, oBIG - omics Bioinformatics for Health
Institutions: Interdisciplinary Center for Bioinformatics (IZBI)
https://orcid.org/0000-0002-2242-4678
Projects: Leipzig Melanoma Studies, GLA - German Lymphoma Alliance, MMML-MYC-SYS, GGN - German Glioma Network, LIFE Adult, LIFE - Leipzig Research Center for Civilization Diseases, Task Force COVID-19 Leipzig, NFDI4Health, LHA - Leipzig Health Atlas, Think different, imSAVAR - Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies, oBIG - omics Bioinformatics for Health, Vine Bioinformatics - grape genomics for Innovative viticulture
Institutions: University of Leipzig, Interdisciplinary Center for Bioinformatics (IZBI)
https://orcid.org/0000-0001-8239-440X
Taxonomy URI: http://purl.obolibrary.org/obo/DOID_1909
Synonyms: malignant melanoma, Naevocarcinoma
Definitions: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.
