Genetic dyslexia risk variant is related to neural connectivity patterns underlying phonological awareness in children.
Phonological awareness is the best-validated predictor of reading and spelling skill and therefore highly relevant for developmental dyslexia. Prior imaging genetics studies link several dyslexia risk genes to either brain-functional or brain-structural factors of phonological deficits. However, coherent evidence for genetic associations with both functional and structural neural phenotypes underlying variation in phonological awareness has not yet been provided. Here we demonstrate that rs11100040, a reported modifier of SLC2A3, is related to the functional connectivity of left fronto-temporal phonological processing areas at resting state in a sample of 9- to 12-year-old children. Furthermore, we provide evidence that rs11100040 is related to the fractional anisotropy of the arcuate fasciculus, which forms the structural connection between these areas. This structural connectivity phenotype is associated with phonological awareness, which is in turn associated with the individual retrospective risk scores in an early dyslexia screening as well as to spelling. These results suggest a link between a dyslexia risk genotype and a functional as well as a structural neural phenotype, which is associated with a phonological awareness phenotype. The present study goes beyond previous work by integrating genetic, brain-functional and brain-structural aspects of phonological awareness within a single approach. These combined findings might be another step towards a multimodal biomarker for developmental dyslexia.
PubMed ID: 26080313
Projects: Genetical Statistics and Systems Biology, LIFE - Leipzig Research Center for Civilization Diseases
Publication type: Not specified
Journal: Neuroimage
Human Diseases: Dyslexia
Citation: Neuroimage. 2015 Sep;118:414-21. doi: 10.1016/j.neuroimage.2015.06.024. Epub 2015 Jun 12.
Date Published: 17th Jun 2015
Registered Mode: by PubMed ID
Views: 2118
Created: 9th May 2019 at 11:21
Last updated: 7th Dec 2021 at 17:58
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