No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene

Abstract:

OBJECTIVE The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort. METHODS We genotyped 171 cases and 179 controls. Cases were subgrouped according to sex, autoantibody profiles, or clinical subsets. RESULTS No association of SSc with C77G was detected in the whole dataset, in subgroups, or in combined analyses with a previous study. CONCLUSION The results do not confirm PTPRC C77G as a general and independent risk factor for development of SSc.

Projects: Genetical Statistics and Systems Biology

Publication type: Journal article

Journal: The Journal of rheumatology

Human Diseases: No Human Disease specified

Citation: The Journal of rheumatology 35(9):1817–1819

Date Published: 2008

Registered Mode: imported from a bibtex file

Authors: Holger Kirsten, Mechthild Blume, Frank Emmrich, Nico Hunzelmann, Rudolf Mierau, Rita Rzepka, Peter Vaith, Torsten Witte, Inga Melchers, Peter Ahnert

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Katrin Horn

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Created: 14th Sep 2020 at 13:07

Last updated: 7th Dec 2021 at 17:58

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