Version 1

The PREMM1,2,6 has been developed as a pretest to decide whether patients suspected of having Lynch syndrome should be tested for germline mismatch repair gene mutations. "PREMM1,2,6" is a logistic regression model. It calculates the risk of having a mutation in the mismatch repair genes MLH1, MSH2 and MSH6 (for single genes and overall) based on the personal and familial cancer history of the proband (colorectal, endometrial, and other Lynch syndrome related cancers).


1 item is associated with this Model:

Human Disease: Hereditary breast ovarian cancer syndrome

Model type: Not specified

Model format: R package

Execution or visualisation environment: Shiny

Model image: No image specified

help Creators and Submitter
Additional credit

Kastrinos et al.


Views: 3822

Created: 13th May 2019 at 14:12

Last updated: 27th Nov 2019 at 12:53

Last used: 17th Jul 2024 at 14:19

help Attributions


Version History

Version 1 Created 13th May 2019 at 14:12 by Silke Zachariae

No revision comments

Related items

Powered by
Copyright © 2008 - 2021 The University of Manchester and HITS gGmbH
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig

By continuing to use this site you agree to the use of cookies