Oana Brosteanu

About Oana Brosteanu:
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LHA ID: 8GK99X1TGV-5

Location:  Germany

ORCID: https://orcid.org/0000-0002-8706-217X

Joined: 22nd Feb 2023

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BASALIT

Coordinating investigators Prof. Dr. Jan C. Simon Prof. Dr. Regina Treudler Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig

Sponsor Universität Leipzig Ritterstr. 26, 04109 Leipzig

EudraCT: 2009-011737-27

Programme: University Leipzig (Sponsor)

Public web page: Not specified

ADIPO-VENT

TitelOptimierung der perioperativen maschinellen Ventilation bei adipösen und normalgewichtigen Patienten durch PEEP-Titration anhand der Elektrischen Impedanz-Tomografie – eine randomisierte kontrollierte klinische StudieStudienleitungProf. Dr. Hermann WriggeKlinik und Poliklinik für Anästhesiologie und IntensivtherapieUniversitätsklinikum LeipzigDRKS0000419

Programme: University Leipzig (Sponsor)

Public web page: Not specified

TIBICO

TitelEffektivität der transnasalen Insufflation (TNI) im Vergleich zur nicht-invasiven BiPAP-Beatmung bei Patienten mit chronisch respiratorischer Globalinsuffizienz bei COPD**Studienleitung:**Prof. Dr. med. Hubert WirtzDr. med. Jens BräunlichUniversität LeipzigDepartment Innere Medizin, Neurologie und DermatologieAbteilung für Pneumologieclinicaltrials.gov: NCT02007772

Programme: University Leipzig (Sponsor)

Public web page: Not specified

GRAFT

TitleGranulocyte colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicentre randomized trialCoordinating investigator:Prof. Dr. Thomas BergSektion Hepatologie, Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Universitätsklinikum LeipzigSponsorUniversität Leipzig Ritterstr. 26, 04109 LeipzigEudraCT: 2015-002212-32ClinicalTrials.gov: NCT02669680

Programme: University Leipzig (Sponsor)

Public web page: Not specified

AbCD

TitleProspective multicentre trial of Antibody diagnostics in paediatric Coeliac Disease**Coordinating investigator:**Prof. Dr. Thomas MothesInstitut für Laboratoriumsmedizin, Klinische Chemie und Molekulare DiagnostikUniversität LeipzigDRKS-No.: DRKS00003854

Programme: University Leipzig (Sponsor)

Public web page: Not specified

STOP-NUC

Coordinating investigator: Prof. Dr. Florian van Bömmel Sektion Hepatologie, Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Universitätsklinikum Leipzig

Sponsor Universität Leipzig Ritterstr. 26, 04109 Leipzig

EudraCT: 2013-004882-15 DRKS: DRKS00006240

Programme: University Leipzig (Sponsor)

Public web page: Not specified

Clinical Trials Leipzig

This project serves as a container for all clinical trial of University of Leipzig (IMISE / ZKS) within the framework of the NFDI4Health

Programme: NFDI - German National Research Data Infrastructure

Public web page: Not specified

NFDI4Health: inactive since

NFDI4Health - the National Research Data Infrastructure for Personal Health Data - deals with data generated in clinical trials, epidemiological and public health studies. The collection and analysis of these data on health and disease status and important factors influencing it are an essential component for the development of new therapies, comprehensive care approaches and preventive measures in a modern health care system. Although these data already meet high content quality standards, they ...

Programme: NFDI - German National Research Data Infrastructure

Public web page: https://www.nfdi4health.de/en

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BASALIT trial: double-blind placebo-controlled allergen immunotherapy with rBet v 1-FV in birch-related soya allergy.
BASALIT

Abstract (Expand)

BACKGROUND: Conflicting results exist on the effect of allergen immunotherapy (AIT) on pollen-related food allergy. We aimed to investigate the efficacy of one-year AIT with the folding variant (FV) … of recombinant (r) Bet v 1 on birch-related soya allergy. METHODS: Of 138 subjects with Bet v 1 sensitization, 82 were positive at double-blind placebo-controlled food challenge (DBPCFC) with soya. A total of 56 of 82 were randomized in the ratio of 2:1 (active: placebo). Per-protocol population (PPP) had received >/=150 mug of allergen or placebo preparation. OUTCOME MEASURES: lowest observed adverse effect levels (LOAEL), postinterventional occurrence of objective signs (objS) at any dose level, sIgE/IgG4 against Bet v 1 and Gly m 4. Between-group changes were investigated (ancova, Mann-Whitney U-test, Fisher exact test). RESULTS: Baseline characteristics including LOAELs were comparable in both groups with objS and subjS occurring in 82% and 95% of active (n = 38) vs 78% and 83% of placebo group (n = 18). After AIT, objS occurred in 24% and 47%, respectively. LOAEL group differences showed a beneficial tendency (P = 0.081) for LOAEL(objective) in PPP (30 active, 15 placebo). sIgG4 raised only in active group (Bet v 1: P = 0.054, Gly m 4: P = 0.037), and no relevant changes occurred for sIgE. Only 56% of the intended sample size was recruited. CONCLUSION: For the first time, we present data on the effect of rBet v 1-FV on birch-related soya allergy. rBet v 1-FV AIT induced significant immunogenic effects. Clinical assessment showed a tendency in favour of the active group but did not reach statistical significance.

Authors: R. Treudler, A. Franke, A. Schmiedeknecht, B. Ballmer-Weber, M. Worm, T. Werfel, U. Jappe, T. Biedermann, J. Schmitt, R. Brehler, A. Kleinheinz, J. Kleine-Tebbe, H. Bruning, F. Rueff, J. Ring, J. Saloga, K. Schakel, T. Holzhauser, S. Vieths, J. C. Simon

Date Published: 21st Dec 2016

Publication Type: Journal article

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STOP-NUC Trial protocol
STOP-NUC
No description specified

Creator: Oana Brosteanu

Submitter: Oana Brosteanu

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University Leipzig (Sponsor)
No description specified

Projects: AbCD, GRAFT, TIBICO, STOP-NUC, BASALIT, ADIPO-VENT

Web page: Not specified

NFDI - German National Research Data Infrastructure

In the German National Research Data Infrastructure (NFDI), valuable data from science and research are systematically accessed, networked and made usable in a sustainable and qualitative manner for the entire German science system. Up to now, they have mostly been available on a decentralised, project-related or temporary basis. The NFDI aims to create a permanent digital repository of knowledge as an indispensable prerequisite for new research questions, findings and innovations. Relevant data ...

Projects: NFDI4Health, Task Force COVID-19 Leipzig, NFDI4Health - TA3 Services, Clinical Trials Leipzig

Web page: https://www.nfdi.de/?lang=en

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