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The lipid-secreting sebaceous glands (SG) are indispensable for maintaining skin structure and function, and may influence whole body’s energy metabolism. SG deregulation is also associated with a number of skin disorders, including but not limited to acne. Here, we exploit the high cellular resolution provided by sebaceous hyperplasia to spatially characterize the human SG transcriptional program. By integrating single-cell spatial transcriptomics, pseudotime analysis, RNA velocity, and functional ...

Creators: Maria Schmidt, Henry Löffler-Wirth, Hans Binder, Marlon Schneider

Submitter: Henry Löffler-Wirth

Data file type: Transcriptomic Data

No description specified

Creators: None

Submitter: Henry Löffler-Wirth

Data file type: Not specified

No description specified

Creators: None

Submitter: Henry Löffler-Wirth

Data file type: Not specified

No description specified

Creators: None

Submitter: Henry Löffler-Wirth

Data file type: Not specified

This workspace contains all data generated by the combiSOM analysis of patient-matched gene expression, DNA-methylation and copy number variation (CNV) of 121 lower grade glioma (LGG) specimen.

Creators: None

Submitter: Henry Löffler-Wirth

Data file type: SOM Data

Molecular profiling of cerebral gliomas distinguishes biologically distinct tumor groups and provides prognostically relevant information beyond histological classification and IDH1/2 mutation status. We performed microarray-based genome- and transcriptome-wide molecular profiling of primary tumor samples from 137 patients with cerebral gliomas, 61 WHO grade II and 76 WHO grade III tumors.

Creators: Henry Löffler-Wirth, Markus Kreuz

Submitter: Christoph Beger

Data file type: Genomic Data

Human Diseases: brain glioma

We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 873 biopsy specimens including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt’s lymphoma (BL), mixed FL/DLBCL lymphomas, primary mediastinal large B-cell lymphoma (PMBL), multiple myeloma (MM), IRF4-rearranged large cell lymphoma, MYC-negative high-grade B-cell lymphomas with Chr. 11q aberration pattern (mnBLL-11q), and Mantle cell lymphoma (MCL).

Creator: Henry Löffler-Wirth

Submitter: Henry Löffler-Wirth

Data file type: Other OMICs Data

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