Motivation: The eClaus model can be used to calculate mutation risks for BRCA1/2 as well as life-time risks for breast cancer in women from families with multiple and/or early onset cases of breast and ovarian cancer. The model can be used to assist genetic counselors in clinical decision making regarding genetic testing, intensified surveillance, and prophylatic surgery.
Description: The Claus model is a genetic breast cancer risk calculation model assuming a single rare, highly penetrant gene. The extended version of the Claus model (eClaus), as implemented in the commercial pedigree drawing software CYRILLIC 2.1.3, calculates BRCA1/2 mutation probabilities and breast cancer risks for female individuals (test persons) based on their personal and familial cancer histories.
LHA ID: 7Q0CEYUHXW-11 item is associated with this Model:
- https://apps.health-atlas.de/pedin/ (Website)
Human Disease: Hereditary breast ovarian cancer syndrome
Model type: Not specified
Model format: R package
Execution or visualisation environment: Shiny
Model image: No image specified
Created: 1st Apr 2019 at 11:01
Last updated: 27th Nov 2019 at 12:53
Last used: 1st Mar 2024 at 00:26