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959 Publications visible to you, out of a total of 959
Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis
Genetical Statistics and Systems Biology

Abstract (Expand)

Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association … study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002). Support comes from a recent genome-wide study, which on its own would have missed identifying the association. Further research into the associating variant will require detailed haplotype analysis, verification in further studies, and research involving intermediate phenotypes or direct functional experiments. This new RA risk factor supports the role of angiogenesis in the disease. Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002). Support comes from a recent genome-wide study, which on its own would have missed identifying the association. Further research into the associating variant will require detailed haplotype analysis, verification in further studies, and research involving intermediate phenotypes or direct functional experiments. This new RA risk factor supports the role of angiogenesis in the disease. Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002). Support comes from a recent genome-wide study, which on its own would have missed identifying the association. Further research into the associating variant will require detailed haplotype analysis, verification in further studies, and research involving intermediate phenotypes or direct functional experiments. This new RA risk factor supports the role of angiogenesis in the disease.

Authors: Peter Ahnert, Holger Kirsten

Date Published: 2007

Publication Type: Journal article

Reply to Loughlin et al.
Genetical Statistics and Systems Biology

Abstract

Not specified

Authors: Sandra Mahr, Holger Kirsten, Brigitte Mueller

Date Published: 2007

Publication Type: Journal article

ITIL - 3LGM^2: Methoden und Werkzeuge für das IT-Service-Management im Krankenhaus
Management of health information systems

Abstract

Not specified

Authors: Alfred Winter, Lutz Ißler

Date Published: 2007

Publication Type: InCollection

3LGM^2-Modeling to Support Management of Health Information Systems
Management of health information systems

Abstract (Expand)

OBJECTIVE: Both regional health information systems (rHIS) and hospital information systems (HIS) need systematic information management. Due to their complexity information management needs a thorough … description or model of the managed information system. METHODS: The three layer graph-based meta-model (3LGM(2)) and the 3LGM(2) tool provide means for effectively describing and modeling HIS by hospital functions, application systems and physical data processing components. The 3LGM(2) tool has been used to model parts of the information system of the health care system of the German federal state Saxony and of the Leipzig University Medical Centre. RESULTS: Experiences showed, that 3LGM(2) is suitable for supporting information management even in rHIS. We explain some benefits for information management in regional as well as local settings. CONCLUSIONS: Acceptance of the 3LGM(2) depends strictly on its integration in management structures on the institutional, regional, and even national or European level.

Authors: Alfred Winter, Birgit Brigl, Gert Funkat, Anke Häber, Oliver Heller, Thomas Wendt

Date Published: 2007

Publication Type: Journal article

Integrated information systems for translational medicine
Management of health information systems

Abstract (Expand)

OBJECTIVES: Translational medicine research needs a two-way information highway between ’bedside’ and ’bench’. Unfortunately there are still weak links between successfully integrated information roads … for bench, i.e. research networks, and bedside, i.e. regional or national health information systems. The question arises, what measures have to be taken to overcome the deficiencies. METHODS: It is examined how patient care-related costs of clinical research can be separated and shared by health insurances, whether quality of patient care data is sufficient for research, how patient identity can be maintained without conflict to privacy, how care and research records can be archived, and how information systems for care and research can be integrated. RESULTS: Since clinical trials improve quality of care, insurers share parts of the costs. Quality of care data has to be improved by introducing minimum basic data sets. Pseudonymization solves the conflict between needs for patient identity and privacy. Archiving patient care records and research records is similar and XML and CDISC can be used. Principles of networking infrastructures for care and research still differ. They have to be bridged first and harmonized later. CONCLUSIONS: To link information systems for care (bed) and for research (bench) needs technical infrastructures as well as economic and organizational regulations.

Authors: Alfred Winter, G. Funkat, A. Haeber, C. Mauz-Koerholz, K. Pommerening, S. Smers, Jürgen Stausberg

Date Published: 2007

Publication Type: Journal article

Strategische Bedeutung des Software Engineering für die Medizin
Management of health information systems

Abstract

Not specified

Authors: Sabine Glesner, Stefan Jähnichen, Barbara Paech, Bernhard Rumpe, Thomas Wetter, Alfred Winter

Date Published: 2007

Publication Type: InCollection

Architekturmodelle für das Management heterogener IT-Landschaften
Management of health information systems

Abstract

Not specified

Authors: B. Brigl, Alfred Winter

Date Published: 2007

Publication Type: Journal article

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