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Published year: 20131
Author: Henry Löffler-Wirth1
Analysis of microRNA expression using machine learning.
LHA - Leipzig Health Atlas

Abstract (Expand)

The systematic analysis of miRNA expression and its potential mRNA targets constitutes a basal objective in miRNA research in addition to miRNA gene detection and miRNA target prediction. In this chapter … we address methodical issues of miRNA expression analysis using self-organizing maps (SOM), a neural network machine learning algorithm with strong visualization and second-level analysis capabilities widely used to categorize large-scale, high-dimensional data. We shortly review selected experimental and theoretical aspects of miRNA expression analysis. Then, the protocol of our SOM method is outlined with special emphasis on miRNA/mRNA coexpression. The method allows extracting differentially expressed RNA transcripts, their functional context, and also characterization of global properties of expression states and profiles. In addition to the separate study of miRNA and mRNA expression landscapes, we propose the combined analysis of both entities using a covariance SOM.

Authors: H. Wirth, M. V. Cakir, L. Hopp, H. Binder

Date Published: 26th Nov 2013

Publication Type: Not specified

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