MegaCHOEP-III MegaCHOEP-III MegaCHOEP-III years months Patient identification number within trial Therapy arm Gender Age (years) IPI factor age>60 years IPI factor LDH>N IPI factor ECOG>1 IPI factor stage III/IV IPI factor extralymphatic involvement > 1 age-adjusted IPI score Extralymphatic involvement Bulky disease B-symptoms Bone marrow involvement Reference pathology diagnosis Event-free survival (months) Event-free survival status Progression-free survival (months) Progression-free survival status Overall survival (months) Overall survival status 8 x CHOEP-14 + 6xR 4 x MegaCHOEP-21 + 6xR male female age <= 60 years age > 60 years LDH <= N LDH > N ECOG <= 1 ECOG > 1 stage I/ II stage III/ IV E <= 1 E > 1 no yes no yes no yes no yes 1040 1044 1093 1010 1080 1090 1070 1035 1036 1050 1060 1045 1100 1000 1120 2030 2060 3040 3060 3050 censored event censored event censored event